• Develop, optimize and validate analytical methods primarily using Thermo Scientific Q-Exactive and Exploris mass spectrometers using LC-MS and other types of mass spectrometric methods to identify and quantify metabolic compounds and exogenous compounds (including carcinogens and toxins).
• Create laboratory developed tests (LDTs) to be implemented in a CLIA environment.
• Design, implement bench-scale experiments with multiple variables for small molecule compounds.
• Be a champion for data quality making judgment calls on qualitative and quantitative validity of analytical data and drive the directions of research projects towards definite conclusions.
• Collaborate cross-functionally with other R&D teams and successfully communicate with people who have little or no knowledge of mass spectrometry and metabolomics.
• Maintain meticulous experimental records.
• Mentor junior team members.
• Voice ideas, concerns, and solutions as an active team member.
• Being able to work in an environment which comes with shifting priorities.

QUALIFICATIONS GUIDELINES

To include, but are not limited to the following:

• Ph.D. degree in Analytical Chemistry, Chemistry, Biochemistry or related fields.

• For Scientist II, 3 years of postdoctoral hands-on laboratory (academic and/or industrial) experience developing analytical methods for small molecule analysis (LC, MS, GC). For Scientist I, 0-3 years postdoctoral experience.

• Ability to be a fully independent user of LC-MS and knowledge of instrumentation hardware and software. 

• Proficiency in Solid Phase Extraction (SPE) is a plus.

• Experience using the Thermo Scientific Q-exactive platform is essential, including data analysis using both Thermo software and open-source software.

• Proficiency in untargeted and targeted metabolomics and lipidomics data processing, statistical analysis and data interpretation is essential.

• Proficiency using Python based analysis tools is desirable.

• Strong problem-solving skills and proven creativity.

• Strong oral and written communication skills.

• Demonstrated ability to work effectively within a diverse and dynamic team.

• Start-up company experience is a plus.

Physical Requirements: standing, sitting, walking, stairs, light lifting, computer operation.

Diagnose Early is an equal opportunity employer. Diagnose Early offers a competitive compensation package including medical/dental, 401K, paid time off, holidays, and equity.