Job Description:

Client is a leading precision oncology company focused on helping conquer cancer globally through use of its proprietary blood tests, vast data sets and advanced analytics.
The Client Oncology Platform is designed to leverage our capabilities in technology, clinical development, regulatory and reimbursement to drive commercial adoption, improve patient clinical outcomes and lower healthcare costs. In pursuit of our goal to manage cancer across all stages of the disease, Client has launched two liquid biopsy-based tests, Client 360 and Client OMNI, for advanced stage cancer patients, and is developing programs for recurrence and early detection, under Project LUNAR. Since its launch in 2014,Client 360 has been used by more than 5,000 on cologists, over 40 biopharmaceutical companies and all 27 of the National Comprehensive Cancer Network centers.

We are looking for a Scientist II or Senior Scientist for our upcoming product launches. The ideal candidate scientist is passionate about data analysis and troubleshooting and is a team player who excels in a cross-functional environment. In the Screening Sustain and Support team, you will collaborate cross-functionally with members of assay development, bioinformatics, process engineering, clinical development, and operations. You will be hands-on both behind the computer and in the lab, executing sustain and support efforts for IVD liquid biopsy sequencing assays for the early detection, treatment and monitoring of all cancer types. 

An ideal candidate has a strong technical nucleic acid biology foundation and experience with NGS assay development for automated platforms in a regulated environment. Preference is given to candidates with experience in monitoring large data sets and interacting with clinical staff.

Essential Duties and Responsibilities

• Lead monitoring and troubleshooting efforts for IVD assays

• Integrate analytical tools and experimental design to identify failure modes in a high throughput sequencing sample preparation and specimen handling workflow.

• Work in a highly collaborative team environment to propose and implement sustaining solutions in a post-deployment regulated environment.

• Operate molecular biology laboratory equipment including automated liquid handlers, quantitation instruments, thermal cyclers, and next generation sequencing instruments.

• Synthesize large datasets and extract relevant trends using NGS data analysis tools (Python, R, IGV, etc.).

• Present data, write reports and protocols, and contribute to technical discussions in various forums to both technical and non-technical audiences.

• Ensure all work is performed and documented in compliance with applicable regulatory and quality practices (CLIA/CAP, IVD (Design Control), ISO13485).

Qualifications

• Strong foundation in molecular biology techniques including sample preparation for NGS

• Quantitative/analytical mindset- ability to segment complex problems into fundamental parts/basic principles, develop models and experimental tests for those models, and synthesize results into actionable solutions

• Demonstrated ability to organize, document and communicate scientific data 

• Consummate team player: demonstrated ability to thrive in an environment where numerous contributions are required to accomplish complex goals

• Enjoy working independently and collaboratively in a fast-paced environment and able to adapt to change

• Curiosity, drive and sense of humor

• Experience in the following areas is highly desirable:

  • Exposure to statistical process control and experience with statistical analysis tools in Python and/or R

  • Product development in a regulated environment 

  • Experience with assay development for automated liquid handling platforms

Education

• PhD in Molecular Biology, Genomics, Biochemistry or related field and 3-5 years of relevant work experience OR

• MS in Molecular Biology, Genomics, Biochemistry or related field and 8-10 years of relevant work experience OR

• BA/BS in Molecular Biology, Genomics, Biochemistry or related field and 10-15 years of relevant work experience