9 Senior Scientist, Analytical Development Jobs in San Carlos, CA
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Senior Scientist, Analytical Development
$134k-173k (estimate)
Full Time
1 Month Ago
CARGO-Therapeutics is Hiring a Senior Scientist, Analytical Development Near San Carlos, CA
CARGO is seeking a self-motivated and versatile individual to join us as a Senior Scientist within the Analytical Development organization. In this position, you will work closely with the Process Development, Quality Control, Quality Assurance, Translational Medicine, Biometrics, and Regulatory team members and will contribute to novel assay development for product understanding of CARGO Therapeutics’ pipeline candidates, fit‑for‑purpose method qualification, SOP/technical report authoring/review, life cycle management of assays, data analysis, and execution of routine analytical testing. This individual should be highly organized, a quick learner, and largely independent.
This is an onsite, lab-based role located in San Carlos, CA.
WHAT YOU’LL DO AT CARGO THERAPEUTICS
- Lead novel and innovative product characterization studies to interrogate immune and CAR T-cell biology through the development and execution of robust analytical flow-based phenotyping and functional methods
- Support the identification of potential Critical Quality Attributes (CQAs) and Critical Process Parameters (CPPs)
- Collaborate closely within Process Sciences and Quality Control groups to support, execute, and provide oversight in method optimization/troubleshooting/root cause investigations, extended process/product characterization, and technology transfer
- Develop extended characterization and release assays, including associated SOPs (Standard Operating Procedures) and technical protocols/reports (transfer, validation, bridging, etc.)
- Successfully execute and document laboratory procedures and experiments with great attention to detail, including Electronic Lab Notebook (ELN) record keeping
- Analyze data and perform integrative correlation analyses and prepare reports or data packages for review
- Perform additional duties as assigned
THE RIGHT STUFF: Required Experience & Qualifications
- Demonstrated experience in cell therapy, immunology, or a closely related field; PhD with 4 years of experience is preferred (MS with 6 years or BS with 8 years will also be considered)
- Industry experience in cell and gene therapy within an Analytical Development role is preferred
- Strong comprehension of T-cell and CAR T biology including principles of memory, exhaustion, senescence, effector function and how these attributes may be influenced by process or vector optimizations
- Experience with assay development, method qualification, and routine testing in GLP and/or GMP environment
- Technical expertise in relevant technologies used in cell therapies, with an emphasis on multiparameter flow cytometry; experience with co-culture assays is preferred
- Prior experience with metabolomic attribute assessment and molecular-based methods including next generation sequencing (NGS) is nice to have, but not required
- Excellent technical writing experience in a regulatory environment such as protocols, reports, and SOPs
- Proficient in MS Word, Excel, and PowerPoint, with knowledge related to scientific data analysis software for applications such as GraphPad Prism, JMP, NovoExpress/FCS Express (flow/spectral cytometry), and R (Seurat, sequencing)
- Availability to work extended hours to meet deadlines and willingness to travel, when necessary
- Comfortable in a fast-paced environment with minimal direction and able to adjust workload based upon changing priorities
- Self-motivated, detail-oriented, and willing to accept temporary responsibilities outside of initial job description
- Highly effective written and oral communication skills to address a wide variety of audiences and governing bodies
- Demonstrated resilience, diplomacy, influence, relationship-building, and problem-solving skills in various situations
PAY RANGE
The combined pay range for this role is $114,000 - $156,000. Title and salary will be based on our assessment of skills and experience relevant to our needs for the role.
ABOUT CARGO THERAPEUTICS
CARGO Therapeutics, Inc. is a clinical-stage biotechnology company positioned to advance next generation, potentially curative cell therapies for cancer patients. CARGO’s programs, platform technologies, and manufacturing strategy are designed to directly address the limitations of approved cell therapies, including limited durability of effect, safety concerns and unreliable supply. CARGO is currently evaluating its lead program, CRG-022, an autologous CD22 chimeric antigen receptor (CAR) T-cell therapy candidate, in a potentially pivotal Phase 2 clinical trial in patients with large B-cell lymphoma (LBCL) whose disease relapsed or was refractory (R/R) to CD19 CAR T-cell therapy. CARGO also plans to evaluate CRG-022 in patients at earlier stages of disease, including LBCL and other hematologic malignancies. Beyond its lead program, CARGO is leveraging its proprietary cell engineering platform technologies to develop a pipeline of programs that incorporate multiple transgene therapeutic “cargo” designed to enhance CAR T-cell persistence and trafficking to tumor lesions, as well as to help safeguard against tumor resistance and T-cell exhaustion. CARGO’s founders are pioneers and world-class experts in CAR T-cell therapy, and its team has significant experience and success developing, manufacturing, launching and commercializing oncology and cell therapy products. For more information, please visit the CARGO Therapeutics website at https://cargo-tx.com/.
Join us to help make a difference!
EEO & EMPLOYMENT ELIGIBILITY
CARGO Therapeutics, Inc. is committed to building a diverse, equitable, and inclusive company. We provide equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability, or veteran status. CARGO Therapeutics, Inc. also complies with all applicable national, state, and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification required of applicable law.
CARGO Therapeutics requires all new hires to be fully vaccinated against COVID-19 as of their start date. This requirement is a condition of employment at CARGO Therapeutics, and it applies regardless of whether the position is located at a CARGO Therapeutics site or is fully remote. If you are unable to receive the vaccine due to a disability or serious medical condition, or because it is prohibited because of your sincerely held religious beliefs, you will have an opportunity to request a reasonable accommodation.
Job Summary
JOB TYPE
Full Time
SALARY
$134k-173k (estimate)
POST DATE
03/15/2024
EXPIRATION DATE
05/14/2024
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