1 Proteomics Scientist (FT) Job in Framingham, MA
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BPGbio is Hiring a Proteomics Scientist (FT) Near Framingham, MA
POSITION SUMMARY:
The highly motivated Principal Scientist will work within the Omics group to develop and apply state-of-the-art proteomics technology to address compelling questions in biology, chemistry, and clinical medicine; This role will join a team responsible for biomarker discovery/validation in multiple disease areas, including neurodegenerative diseases and cancer;
The highly motivated Principal Scientist will work within the Omics group to develop and apply state-of-the-art proteomics technology to address compelling questions in biology, chemistry, and clinical medicine; This role will join a team responsible for biomarker discovery/validation in multiple disease areas, including neurodegenerative diseases and cancer;
ESSENTIAL DUTIES AND RESPONSIBILITIES:
- Spearhead technical analysis of post-translational modifications (phosphorylation, acetylation, ubiquitinylation, etc;) Contribute to the assessment of chemo proteomic analysis for MOA of specific compounds under investigation;
- Identify the mechanism of action of drugs and drug-like molecules, developing and optimizing novel, broadly enabling proteomic technologies including targeted, quantitative MS assay development for proteins and modifications;
- Collaborate closely with analytical biochemistry, molecular biology, and computational research staff to design, plan, and perform experiments, collect data, and conduct data analysis;
- Mentor research associates;
- Other duties as assigned.
REQUIREMENTS:
- Requires a Ph.D.; degree in Biology, Biochemistry, Chemistry, or Analytical Sciences with relevant postdoctoral experience and 3-5 years of experience with nanoLC-MSMS analysis using HR/HA mass spectrometry instruments;
- A strong background in state-of-the-art proteomics, more specifically post-translational modification analysis; some experience in cell biology, signaling, and/or systems biology;
- Familiarity with high-throughput quantitative methodologies such as TMT® and Label-free approaches;
- Ability to apply and/or develop affinity/activity-based proteomic probes to profile the functional state of enzyme targets in native biological systems and assess the selectivity of compounds;
- Ability to work with an interdisciplinary team of biologists, chemists, and computational scientists to deeply characterize and understand the proteomes of cells, biofluids, and tissues;
- Demonstrated ability to analyze, interpret, and present data;
- Solid scientific training/productivity as identified through high-impact publications demonstrating creative thinking as well as innovative technical approaches;
- Experience with Thermo instrumentation platforms is a plus.
Job Summary
JOB TYPE
Full Time
SALARY
$131k-163k (estimate)
POST DATE
03/26/2023
EXPIRATION DATE
06/09/2024
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