Do you want to be part of an inclusive team that works to develop innovative therapies for patients? Every day, we are driven to develop and deliver innovative and effective new medicines to patients and physicians. If you want to be part of this exciting work, you belong at Astellas!

Astellas Pharma Inc. is a pharmaceutical company conducting business in more than 70 countries around the world. We are committed to turning innovative science into medical solutions that bring value and hope to patients and their families. Keeping our focus on addressing unmet medical needs and conducting our business with ethics and integrity enables us to improve the health of people throughout the world. For more information on Astellas, please visit our website at www.astellas.com .

About Astellas Gene Therapies

Astellas Gene Therapies is an Astellas Center of Excellence developing genetic medicines for patients with rare, life-threatening diseases. Based on our innovative approach to developing genetic medicines, as well as our industry-leading internal manufacturing capability and expertise, we have become the Astellas Center of Excellence for their newly created Genetic Regulation Focus Area. We are currently exploring three gene therapy modalities: gene replacement, exon skipping gene therapy, and vectorized RNA knockdown, with plans to expand our focus and geographic reach under Astellas. We are based in San Francisco, with manufacturing and laboratory facilities in South San Francisco and Sanford, North Carolina. For more information, please visit our website: www.astellasgenetherapies.com.

The Role

The Research Associate II, or Sr Research Associate will work closely with the Analytical Development team in the Tech Dev department to develop methods and test samples utilizing PCR, ELISA, Gel Electrophoresis, cell-based and other assays; as well as to contribute to design and performing experiments with supervision as needed; complete assigned tasks within time frames with high quality; maintain a well-documented record of activities in ELN and reports. Additionally, the role includes regularly summarizing and presenting experimental results in meetings, and responsible for generating reports. The position level will be commensurate with education and experience level. This role will be at our South San Francisco R&D facility.

Responsibilities:

• Develop and optimize assays for protein, DNA, and adeno associated viral (AAV) nanoparticles

• Develop cell-based assay.

• Perform routine testing including but not limited to PCR (ddPCR, qPCR etc.), ELISA, Gel Electrophoresis, and cell-based assays following SOP and regulatory guidelines

• In volve in assay transfer to other groups, QC, testing group and Research

• Participate in writing, reviewing, and editing experimental procedures and reports

• Maintain accurate, error-free records of all analytical development activities timely

• Analyze and determine the applicability of laboratory data to draw conclusions and to make appropriate recommendations

• Present on group or departmental meetings

Required Qualifications:

• Bachelor of Science or a Master’s degree with 2 years’ experience working in pharmaceutical or biotech company performing biologic assays for characterization of proteins, DNA, RNA, virus or other biological products.

• Proven experience with assays, such as PCR, ELISA, and mammalian cell-based assays.

• Proven hands-on experience with sterile technique for handling and growing mammalian cell lines, including maintenance, cell characterization and differentiation, expansion, and banking

• Experience or knowledge with routine molecular biology techniques (DNA/RNA/protein isolation, cDNA synthesis, RT-PCR, qPCR, digital PCR, western blot, and immunofluorescence)

• Positive, professional self-starter with a passion for science, innovative technical and analytical skills required to perform at the highest level

• Highly motivated and independent yet has successfully worked in a group setting with efficient, flexible and self-motivated work ethic; to be utilized in work planning, executing, and data analyzing.

• Excellent clear and concise writing skills for technical reports and documents along with strong verbal communication skills

• Proven ability to work in cross-functional teams as a strong team player as well as independently.

• Successful history and the ability to handle several fast-paced projects concurrently.

• Excellent communication, writing and presentation skills to technical and non-technical audiences.

• Proficient working in Microsoft Office Suite

Preferred Qualifications:

• Experience working with Adeno-Associated Virus (AAV)

• Experience in analytical method development and assay transfer

• Experience in statistical analysis

Salary Range : $72,800 - $97,000 (NOTE: Final salary could be more or less, based on experience)

Benefits:

• Medical, Dental and Vision Insurance

• Generous Paid Time Off options, including Vacation, Sick time, plus national holidays including Heritage Days, and Summer and Winter Breaks

• 401(k) match and annual company contribution

• Company paid life insurance

• Annual Corporate Bonus and Quarterly Sales Incentive for eligible positions

• Long Term Incentive Plan for eligible positions

• Referral bonus program

All qualified applicants will receive consideration for employment without regard to race, sex, color, religion, sexual orientation, gender identity, national origin, protected veteran status, or on the basis of disability.

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Category GT - Technical Development

Astellas is committed to equality of opportunity in all aspects of employment.

EOE including Disability/Protected Veterans