JOB SUMMARY

The Strain Development Scientist will be accountable for defining and developing cell line for plasmid DNA manufacturing for Arranta Bio’s RNA manufacturing platform. You will be an integral part of the Nucleic Acid Technology Group and will play a critical role in establishing a robust, reliable and scalable manufacturing platform for Arranta Bio with accountability on delivering wide range of solutions from RNA therapeutics, vaccines and novel RNA chemistries. The ideal candidate will be a fast-paced detail oriented cross functional coach with technical expertise in strain development.

ESSENTIAL JOB FUNCTIONS

• Design, develop, screen and bank stable cell lines for producing plasmid DNA using E. coli.

• Develop appropriate quality control assays to ensure stability of the cell line and quality of the plasmid DNA in research cell banks.

• Collaborate to develop, design, test and build experimental workflows in order to operationalize new methods of DNA production.

• Analyze experimental data and generate data driven conclusions for strain design, development and optimization.

• Design and execute fermentation studies to improve process improvements in shake flasks.

• Interface with multi-disciplinary team (Analytical Development, Process Science, Manufacturing, Process Engineering & Quality) to deliver on-time deliverables for all projects.

• Represent Arranta in current and prospective client interactions as a subject matter expert and serve as technical lead on client programs.

• Authors, executes and leads development plans, development reports and investigations including contributions to regulatory submissions.

• Provides coaching, training and oversight of other scientific and laboratory staff.

• Utilize DoE and QbD principles for efficient development of processes.

• Adheres to good laboratory practices and standard operating procedures.

• Must demonstrate proficient skills in organization, attention-to-detail, interpersonal communication, judgement, planning and prioritization.

• Establish written procedures for the clear and accurate documentation of equipment operation, process instructions and process data.

• Maintain a clean, organized, and safe work environment with a continuous improvement mindset.

• M.S degree in degree in Microbiology, Biology, Chemistry, Biochemistry, Biological Engineering, Biotechnology or Chemical Engineering with 3 years of relevant work experience.
• Ph.D. Degree in Microbiology, Biology, Biochemistry, Biological Engineering, or Chemical Engineering.
• Level contingent on experience.
• Demonstrated academic/industry experience in plasmid assembly and manipulation, sequencing, DNA purification, and cell transformation.
• Experience with bacterial hosts other than E. coli is a plus.
• Familiarity with analytical techniques in nucleic acid and protein detection and quantification (such as AGE, Bioanalyzer, RNA Dot-Blot, UV-Vis spectroscopy and Fragment Analyzer) is a plus.
• Excellent oral and scientific writing communications skills is required.
• Ability to independently perform experiments, analyze complex data and report data with simplicity is critical for success.
• Proficiency with DoE using statistical software (ex - JMP) is required.
• Familiarity and practical understanding of how to correctly operate basic laboratory equipment: including microbial culturing, aseptic techniques, bioreactors, pH/conductivity meters, lab scales, centrifuges, shakers, sterile hoods, pipettes, etc is preferred.
• Must have strong mathematical, computational, problem solving, planning and organizational skills.
• Must be flexible, approachable, highly motivated and good interpersonal skills.

PHYSICAL DEMANDS

The physical demands described here are representative of those that must be met by an employee to successfully perform the essential functions of this job. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

• While performing the duties of this job, the employee is frequently required to stand; sit; use hands to finger, handle, or feel; reach with hands and arms; and talk or hear.

• The employee is occasionally required to walk; climb or balance; and stoop, kneel, crouch, or crawl.

• The employee must frequently lift and/or move up to 10 pounds and occasionally lift and/or move up to 25 pounds.

• Specific vision abilities required by this job include close vision, and ability to adjust focus.

• The employee will be required to communicate using telephone and e-mail.

MEDICAL REQUIREMENTS

COVID19 Vaccine required to come on site; Individuals seeking an exemption from this requirement for medical or religious reasons should reach out to Human Resources for an accommodation

ABOUT US

Arranta Bio is a visionary contract development and manufacturing organization (CDMO) that partners with companies seeking to develop and manufacture complex biological drugs and innovative therapies. Our dedicated team, state-of-the-art facilities, and unparalleled resources are crucial for advancing products from development to commercial launch. Our vision is to be the trusted and innovative CDMO partner for advanced therapy pioneers, so that we can bring life-changing therapeutics to patients. We partner with our clients to make treatments that can benefit vast patient populations, working across many indications. Arranta Bio’s mission is to change healthcare through our intrepid and daring team engaging with clients to develop, manufacture, and supply breakthrough therapies that transform lives. Arranta Bio continues to expand capacity and development and manufacturing services across multiple sites with technology platforms designed to meet the evolving demands of our clients and partners.

WHO ARE WE

Arranta hires people who are committed and passionate to the goal of bringing life enhancing products to patients. We want top talent who will render ideas and a relentless desire towards accomplishing our mission; when a job becomes a passion, it makes you feel ALIVE.

Here at Arranta Bio, we embrace ALIVE - our core values that we live and breathe daily! We are Agile, Leading, Innovating, Value Creating, and Engaging. Are you ready to come ALIVE with a daring and intrepid team? Don’t wait another minute; Apply today!

Arranta Bio is an Equal Opportunity Employer.

BENEFITS

• Phone reimbursement policy for qualified individuals
• Free parking
• Highly competitive healthcare with many plan options:

• Medical (HMO/PPO/EPO)
• Dental
• vision
• Flexible Spending Accounts for medical expenses and dependent care expenses
• Up to 10 weeks of 100% paid maternity leave
• 2 weeks of 100% paid paternity, domestic partner, & adoption leave
• Educational assistance program
• 401K plan allows for up to a 6% company contribution
• A suite of Arranta Bio paid insurance coverage, including life insurance, short-term and long-term disability
• Voluntary legal assistance plan
• Employee Referral program
• Competitive PTO plan, in addition to 10 company paid holidays (includes 2 floating holidays)
From: Arranta Bio
Benefits:
• Phone reimbursement policy for qualified individuals
• Highly competitive healthcare with many plan options:
• Medical (HMO/PPO/EPO)
• Dental
• Vision
• Flexible Spending Accounts for medical expenses and dependent care expenses
• Up to 10 weeks of 100% paid maternity leave
• 2 weeks of 100% paid paternity, domestic partner, & adoption leave
• Educational assistance program
• 401k (traditional and Roth offered) with 100% match on first 5% deferred.
• A suite of Arranta Bio paid insurance coverage, including life insurance, short-term and long-term disability
• Voluntary legal assistance plan
• Employee Referral program
• Competitive PTO plan, in addition to 10 company paid holidays (includes 2 floating holidays)