About Arc Institute

The Arc Institute is a new scientific institution that conducts curiosity-driven basic science and technology development to understand and treat complex human diseases. Headquartered in Palo Alto, California, Arc is an independent research organization founded on the belief that many important research programs will be enabled by new institutional models. Arc operates in partnership with Stanford University, UCSF, and UC Berkeley.

While the prevailing university research model has yielded many tremendous successes, we believe in the importance of institutional experimentation as a way to make progress. These include:

• Funding: Arc will fully fund Core Investigator’s (PI’s) research groups, liberating scientists from the typical constraints of project-based external grants.
• Technology: Biomedical research has become increasingly dependent on complex tooling. Arc Technology Centers develop, optimize and deploy rapidly advancing experimental and computational technologies in collaboration with Core Investigators. 
• Support: Arc aims to provide first-class support—operationally, financially and scientifically—that will enable scientists to pursue long-term high risk, high reward research that can meaningfully advance progress in disease cures, including neurodegeneration, cancer, and immune dysfunction.
• Culture: We believe that culture matters enormously in science and that excellence is difficult to sustain. We aim to create a culture that is focused on scientific curiosity, a deep commitment to truth, broad ambition, and selfless collaboration.

Arc scaled to nearly 100 people in its first year. With $650M in committed funding and a state of the art new lab facility in Palo Alto, Arc will continue to grow quickly to several hundred in the coming years.

About the position

We are looking for an Associate Director to join our Genome Engineering Technology Center and lead the development of cutting-edge functional genomics approaches focused on the high-throughput interrogation of mammalian genomes, transcriptomes and epigenomes with rich multi-omic readouts. You will work closely with scientists and research associates in Arc’s Technology Centers and Core Investigator labs with a mission to develop technology to understand and treat complex genetic disease. The ideal candidate will have a passion for technology development and a proven track record in developing high-throughput CRISPR screens in mammalian cells.

This is an excellent opportunity for a highly motivated and curious scientist and project leader interested in the intersection of basic research and biotech product development. Title and compensation will be competitive with industry jobs relative to experience level and background.

About You

• You are a leader and an expert in functional genomics. You think about gaps in the functional genomics space and know the kind of hiring that needs to be done to fill those gaps.
• You are innovative. You think deeply about what cutting-edge tools and technologies you and your team can develop to better understand human health.
• You are a collaborator. You’re an expert in your domain and you greatly enjoy working successfully with scientists from other teams, labs, and scientific domains. You believe that working on projects with scientists from different scientific backgrounds can lead to the most exciting and successful research.
• You are a problem solver and don’t shy away from tackling ambitious, large-scale projects. You’re motivated to push what is possible in combining the highest data quality standards with speed and scale.
• You are curious. You’re always eager to learn new biology and expand your scientific horizon.

In this position, you will 

• Aid in building and managing the functional genomics team through recruiting, mentoring, and training a team of scientists and research associates
• Drive functional genomics technology development in collaboration with Arc’s Core Investigators and other Technology centers to execute our ambitious, large-scale effort for single-cell perturbations to drive the development of the best-in-class, generalized ML model in this space in collaboration with the rest of Arc
• Serve as a domain expert in functional genomics and pooled screens across the organization via a highly collaborative approach
• Successfully execute project management, data management, and team coordination across your group and larger collaborations to drive internal clarity and progress
•  Present data in internal and external meetings and through various forms of publication

Job Requirements

• PhD in molecular biology, bioengineering, genomics, cell biology, or similar fields
• 8 years of post-PhD experience in academia or the biotechnology industry
• 3 years of previous managerial experience leading and growing scientific teams of 3
• Demonstrated ability to develop novel functional genomics screens with a record of academic publications or intellectual property
• Deep understanding of CRISPR editing systems and their application to pooled screens
• Hands-on experience with culturing various mammalian cell types including cancer cell lines, stem cells, and primary cells
• Ability to design editing reagents for high-throughput pooled screens and analyze large, complex data sets using tools such as Python and R
• Ability and desire to work in a fast-paced environment and be a team player

The base salary range for this position is $151,600 to $190,320. These amounts reflect the range of base salary that the Institute reasonably would expect to pay a new hire or internal candidate for this position. The actual base compensation paid to any individual for this position may vary depending on factors such as experience, market conditions, education/training, skill level, and whether the compensation is internally equitable, and does not include bonuses, commissions, differential pay, other forms of compensation, or benefits. This position is also eligible to receive an annual discretionary bonus, with the amount dependent on individual and institute performance factors.