Our mission is to develop therapies that empower the immune system to combat neurodegeneration and our team is focused on developing treatments for some of the most challenging diseases facing our society. We are supported in this mission by experienced and accomplished scientists and clinicians, a novel portfolio of programs, leading healthcare investors, and pharma company partners, who share in our commitment to bettering the lives of patients and realizing a world where we make brain disorders history
The Biology group at Alector supports pipeline drug development efforts through evaluating new targets, supporting therapeutic candidate screening and selection, as well as informing indication/patient selection through designing and completing critical preclinical studies. As a Senior Scientist in Biology, you will support project teams in developing therapeutic strategies, selecting therapeutic candidates, and delineating their mechanism of action. You will develop and implement in vitro cell-based assays and oversee pre-clinical in vivo study implementation. You will identify and communicate with contract research organizations to augment our internal capabilities.
During the first year, your goals will include:

• Identify program-relevant areas of investigation, develop, and implement experimental in vitro and in vivo strategy
• Drive the evaluation and selection of screening assays in collaboration with the antibody engineering and protein science groups
• Analyze, interpret, and present data to project teams and partners
• Collaborate with scientists across multiple therapeutic areas and functions
• Manage external collaborations or activities with CROs
• Coordinate data management, data analysis and presentations, and contribute to decision making in a collaborative and timeline-driven manner
• Help train and mentor junior researchers

We'd love to hear from you if you have:

• A PhD in Immunology and/or Neuroscience with 3-5 years industry experience
• A record of success in a cross-functional team environment
• Cell-based assay development expertise, ideally in microglia or myeloid biology
• Experience in lysosome and/or autophagy research is a plus
• Experience with designing preclinical PK/PD rodent studies
• Proficiency in cell biology and biochemistry techniques, including mammalian cell culture, protein transfection, immunofluorescence staining, histological techniques, FACS, western blot, ELISA/MSD
• You are meticulous and have strong organizational skills in data management, timeline management
• You have excellent interpersonal, communication and presentation skills
• You are excited with the prospect of positively influencing project direction and strategy by generating robust and high quality data
• You take pride in being self-motivated and a creative problem solver, and value collaboration
• You have a point of view, but are low ego

$120,000 - $155,000 a year
Base salary ranges will be determined by the candidate's level, qualifications, skill set, and experience.
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At Alector, our vision is bold, people are our priority, and our values are at the core of everything we do. Our dynamic and flexible environment encourages our teams to experiment, take ownership of decisions, and question convention to solve complex problems. We value shared wins, perseverance, and a growth mindset, which drives us forward, together.
Among the things you'll discover at Alector from your very first day are our committed and driven colleagues, a bold company vision, and new, modern offices designed to inspire innovation and collaboration in South San Francisco, right at the heart of Biotech Bay. Our benefits are thoughtfully designed around Alectorians and their loved ones and include flexible hybrid work options, competitive compensation, and comprehensive and unique benefits that enhance your health and well-being. Come join us!
We believe that hard-working teams include people from a wide variety of backgrounds and experiences who can challenge each other's assumptions with fresh perspectives and bring creative ideas to the table. We are committed to building an open, diverse, and inclusive environment for all employees. We do not discriminate on the basis of race, religion, color, national origin, sex, gender, sexual orientation, age, marital status, veteran status, or disability status, or any other characteristics protected under applicable federal, state, or local laws.
We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, perform essential job functions, and receive other benefits and privileges of employment. Please contact us to request accommodation.
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