About Acrivon Therapeutics, Inc.

Acrivon (NASDAQ: ACRV) is a clinical stage biopharmaceutical company developing precision oncology medicines that it matches to patients whose tumors are predicted to be sensitive to each specific medicine by utilizing Acrivon’s proprietary proteomics-based patient responder identification platform, Acrivon Predictive Precision Proteomics, or AP3. The AP3 platform enables the creation of drug-specific proprietary OncoSignature® companion diagnostics that are used to identify the patients most likely to benefit from Acrivon’s drug candidates, referred to as patient responders. The name Acrivon (derived from Greek for “accurate”) embodies how our OncoSignature® tests link the patient’s active tumor-driving mechanisms with the drug’s mode-of-action to accurately match our therapies with patients who will benefit independent of underlying genetic tumor alterations.

Acrivon is currently advancing its lead candidate, ACR-368, a selective small molecule inhibitor targeting CHK1 and CHK2 in a potentially registrational Phase 2 trial across multiple tumor types, which the AP3 platform predicts will have a high proportion of patient responders based on OncoSignature®-predicted sensitivity to ACR-368. In addition to ACR-368, Acrivon is also developing internally-discovered preclinical stage pipeline programs targeting critical nodes in the DNA Damage Response, or DDR, and cell cycle regulation pathways, including WEE1, a protein kinase, and PKMYT1, a closely related protein serine/threonine kinase.

Our global team operates out of two leading life science clusters, Watertown, MA and Medicon Village in Lund, Sweden.

Position Overview:

In this highly visible role, you will report directly to the Vice President of Clinical Operations and will interact on a regular basis with the broader executive team. The position’s primary responsibilities are focused on several areas including, but not limited to, implementation of clinical studies; building and managing relationships with Contract Research Organizations (CROs) and academic collaborators; overseeing the creation and implementation of standard operating procedures for clinical operations; contributing to the creation and implementation of the overall clinical strategy of Acrivon. The ideal candidate will need to have experience driving early to late phase clinical programs in precision medicine or CDx based programs in oncology.

Duties and Responsibilities:

• Developing, implementing, and/or managing adequate systems and procedures to ensure efficient day-to-day operations that meets clinical trial needs. Ensuring compliance with established clinical and regulatory guidelines, operating systems and procedures in clinical trials.

• In conjunction with VP of Clinical Operations, help to outline the scope of clinical trial programs with resource needs, timelines, and cost of services.
• Providing oversight and support to Clinical Operations and Project Management areas at CROs to ensure their ability to meet Acrivon’s clinical, regulatory and business objectives through efficient completion of the tasks delegated to them, including, but not limited to:
  • • Tracking and collaborating on the management of study budgets and contract negotiations with vendors and clinical trial
    • Facilitating and tracking payments to vendors and clinical trial investigators.
    • Ensuring the quality of clinical trial initiation, study execution, conduct and close-out of clinical trial/program.
    • Coordinating all Clinical Operations activities, resolving trial execution conflicts, and providing status reports as required.
    • Interfacing with other functional areas such as Biomarker team to proactively identify and, if possible, resolve issues or delays that could impact timely clinical study completion.

Requirements and Qualifications:

• Minimum of a bachelor’s degree in a scientific or health-related discipline.
• Minimum of 6-8 years of Clinical Operations and Clinical Trial Management experience at a contract research organization, biotech or pharmaceutical company preferably in early to mid-phase oncology and/or precision medicine oncology.
• Proven leadership skills managing cross-functionally in a matrix environment.
• Demonstrated ability to build strong relationships with external partners, CROs, and vendors including extensive experience managing contracts and clinical finance activities.
• Excellent written and oral communication skills.
• Excellent organizational skills with ability to multi-task.
• Demonstrated ability to work effectively with representatives from a broad range of scientific disciplines.