About the Company

Pinetree Therapeutics, Inc. is a biotech startup developing bispecific antibodies for cancer therapy. Our mission is to deliver on the promise of therapeutic antibodies to treat drug resistant cancers and immune disorders and create the next generation of transformative medicines for patients. We are a group of highly motivated, dedicated professionals working collaboratively in a multi-facetted team with the ultimate goal to improve patient care. Pinetree Therapeutics is located near Fresh Pond, in West Cambridge.

Job Summary:
We are looking for a Scientist / Senior Scientist to join our team. This individual will lead research projects focused on the discovery and characterization of bispecific antibodies for protein degradation in immune-related diseases. This role involves developing immuno-assays and collaborating with cross-functional teams to drive the mission of advancing therapies for immune-related diseases.

Key Responsibilities:

• Independently design, develop, and validate novel immuno-assays for characterizing therapeutic candidates in autoimmune and inflammatory diseases.
• Lead projects focused on bispecific antibody development targeting immune disease pathways.
• Design and execute in vitro and in vivo studies to evaluate therapeutic efficacy in immune diseases.
• Conduct in-depth immune profiling of preclinical models to understand mechanisms of action and identify disease-specific biomarkers.
• Develop and optimize ex vivo cell-based functional assays using cell lines, primary cells, and whole blood to support target validation, antibody drug screening, mechanism of action studies, and biomarker identification in preclinical and IND-enabling spaces.
• Collaborate with cross-functional teams to integrate findings into broader immunology research and development strategies.
• Stay current on the latest advancements in immunology and contribute through publications, patent applications and presentations.
• Analyze and communicate research data to stakeholders.

Qualifications:

• Ph.D. in Immunology or a related field with 2 years of relevant experience or M.S. in Immunology or related field with 5 years of relevant experience.
• Proven expertise in immune cell biology and immune diseases, and ex vivo immunology assays.
• Experience in multi-color flow cytometry for immunophenotyping human cells (from blood or tissues), assessing immune response, and evaluating cell signaling pathways.
• Experience with immunoassay platforms (e.g., ELISA, Meso Scale Discovery) for measuring analytes in serum, plasma, supernatant, or cell lysates.
• Familiarity with immune diseases, including current research and drugs in development.
• Strong analytical and problem-solving skills with a record of scientific innovation and publications.
• Excellent communication and collaboration skills.
• Self-motivated scientist who can generate scientific questions and design experiments to address them.
• Experience in biomarker discovery, platform-synergistic drug combinations, and large data analysis is a plus.

What We Offer:

• Opportunity to contribute to groundbreaking research in immunology and related diseases.
• Collaborative, inclusive work environment fostering innovation and career development.
• Competitive compensation and comprehensive benefits.
• Pinetree Therapeutics offers·an opportunity to be at the forefront of immuno-oncology research, contributing to the development of next-generation cancer therapies. This is a chance to work in a collaborative, supportive, and inclusive work environment where innovation thrives, and career development is encouraged.

Pinetree is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person’s race, color, gender, age, religion, national origin, ancestry, disability, veteran status, genetic information, sexual orientation or any characteristic protected under applicable law. Pinetree will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Recruitment & Staffing Agencies: Pinetree does not accept unsolicited resumes from any source other than candidates. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of Pinetree, and Pinetree will not owe any referral or other fees with respect thereto.

Job Type: Full-time

Benefits:

• 401(k)
• 401(k) matching
• Commuter assistance
• Dental insurance
• Flexible spending account
• Health insurance
• Paid time off
• Relocation assistance
• Stock options
• Vision insurance

Schedule:

• 8 hour shift
• Monday to Friday

Ability to Commute:

• Cambridge, MA 02138 (Required)

Work Location: In person