GenEdit is a rapidly-growing, early-stage company that is developing a proprietary and novel delivery platform with the potential to transform genetic medicine. Our interdisciplinary team works together across chemistry, payload design, formulation, and screening and preclinical groups to develop the next generation of gene therapies. GenEdit fosters an exciting and dynamic environment where we value impactful data and creative solutions to accelerate our progression from a platform technology to a pipeline of therapeutic candidates. We are seeking talented and motivated individuals to join our team and are expanding across all functions within the organization. Join us in South San Francisco, CA, to be at the forefront of the future of gene therapy.
We are seeking a talented and motivated scientist to join our team and drive the development of genetic medicines for immune-based diseases utilizing our hydrophilic nanoparticle (HNP) technology. This individual will report to the Project Lead Scientist of the Immune Program and will be responsible for planning and executing short and long-term R&D strategy. She/he will be a key contributor to project design, goal setting, method development, and HNP and payload screening to identify lead therapeutic candidates that meet strict in vitro and in vivo target criteria for tissue and cell-specific delivery of nucleic acid payloads that achieve desired immune modulating activity. The ideal individual will have a strong background in cellular immunology, immune modulation and tolerance, vaccines, gene therapy, primary APC models, and rodent models of immune-based diseases. Individuals with industry experience as a key contributor on multiple project teams and collaborations and a successful track record of teamwork are preferred. Position title will be commensurate with scope of responsibilities and years of relevant experience.
Responsibilities
• Lab: Plan and execute complex In Vitro and In Vivo immunology studies including study design, method development, independent data analysis, and technical problem solving. (60-75%)
• Leadership: Assist in goal setting and strategy, planning and resource management, mentorship (commensurate with experience), and study execution to ensure timely achievement of corporate milestones and goals. Function internally as a key opinion leader in matters related to immunology and tolerance.
• Supervisor: May manage Research Associate(s) depending on experience including: workflow organization, goal setting, assigning objectives, mentoring, performance evaluation, skills and career development.
• Collaboration and communication: Work cooperatively with peers and multidisciplinary teams, keep detailed and organized lab records, and present results at team, internal company, and external alliance meetings.
Education and Qualifications
•Ph.D or equivalent in Immunology or a related life science field.
•Five (5) years of academic or biotech/pharma experience with in vitro primary human APC models and developing immunological endpoint assays in rodents is required. Applicants with strong academic research in immune tolerance and autoimmune diseases is highly desired.
•Broad and deep knowledge related to primary immune cell culture and differentiation, immune cell phenotyping, and functional assays, DC and macrophage biology, and immune modulation. Knowledge of vaccine development and gene therapy/delivery a plus.
•Extensive technical expertise:
- Primary immune cell culture models of APC, DC, monocyte, macrophage, and T cells including in vitro and ex vivo functional assays.
- Design and execution of in vivo studies to evaluate therapeutic drug candidates for safety and efficacy in mouse models of autoimmune and inflammatory diseases
- Proficiency with comprehensive immune cell phenotyping by multicolor (12 ) flow cytometry (Attune, CytoFlex), ICC (Cytation), cytokine (MSD), ELISA, ELISpot, and ICS, and related assays.
- In vitro and In vivo screening of drug candidates, microplate cell assays, protein expression, cytotoxicity, fluorescent cell and tissue imaging, luminescence, BLI (IVIS), quantitative microscopy and image analysis.
- Preferred experience with molecular biology techniques including characterization of nucleic acid and protein therapeutic payloads.
•Work authorization in the US is required.
Abilities and Attributes
•A highly professional, enthusiastic, and goal-focused scientist and team player.
•Intellectually agile, curious, and able to thrive in a fast-paced, dynamic environment.
•Excels at technical innovation and creative problem prevention and solution.
•Open-minded, cooperative, and capable of adapting quickly.
•Experience working collaboratively across functional groups and with external partners.
•Personable, sociable, and eager to help build Genedit's culture and future.
At GenEdit we are always looking to hire the absolute best talent and recognize that diversity in our experiences and backgrounds is what makes us stronger. We hire candidates of any race, color, ancestry, religion, sex, national origin, sexual orientation, gender identity, age, marital or family status, disability, veteran status, and any other status. These differences are what enable us to work towards the future we envision for ourselves, and the world.