**CRISPR Therapeutics**

**Research Associate II, Oligonucleotide Synthesis, Non-viral Delivery**

**Non-Viral Delivery - Cambridge, MA - Full Time**

**Company Overview**

At CRISPR Therapeutics, we are focused on developing transformative gene-based medicines for serious human diseases. We are rapidly translating our CRISPR/Cas9 gene editing platform into therapies to treat hemoglobinopathies, cancer, diabetes, and other diseases. Our multi-disciplinary team of world-class researchers and drug developers is committed to translating CRISPR/Cas9 technology into breakthrough human therapeutics. Our lead program targeting the blood diseases ?-thalassemia and sickle cell disease has entered clinical testing, and our immuno-oncology programs focused on CRISPR/Cas9-edited allogeneic CAR-T cell therapies have the potential to deliver the next generation of cancer therapies to patients.

**Job Summary**

CRISPR Therapeutics is seeking a highly motivated Research Associate to join our Non-viral Delivery team in Cambridge, Massachusetts. The incumbent will be responsible for the synthesis and analysis of oligonucleotides to support the generation of guide RNAs with novel chemistries. This position will support therapeutic programs in multiple disease areas and will contribute to the development of a novel nucleic acid conjugation platform. Prior experience in oligonucleotide synthesis and characterization is desired.

**Responsibilities**

* Synthesis, deprotection, purification, annealing and lyophilization of oligonucleotides to support all therapeutic areas

* Analytical characterization of the oligonucleotides for purity determination and impurity profiling

* Support of new chemistry discovery for the development of a novel oligonucleotide conjugation platform

* Operation, maintenance, and troubleshooting of lab instruments, including oligonucleotide synthesizers, purification systems, and HPLC and LC-MS systems

* Maintenance of an accurate and up-to-date record of experiments and results in the form of ELN entries and written reports

* Communication of key findings in group and cross-functional team meetings

* Contribution to regulatory and IP filings

* Performance of laboratory work in safe, efficient manner that ensures a safe working environment for all colleagues

**Minimum Qualifications**

* MS degree in Chemistry, Chemical Engineering, Biochemistry, Bioengineering or related field, or BS degree in a similar field and 3 years of relevant experience

* Working knowledge of nucleic acid chemistry and familiarity with oligonucleotide synthesis, deprotection and purification techniques

* Experience with bioanalytical techniques, such as RP-UPLC, SAX-HPLC, and LC-MS, as well as data interpretation

* An educators mindset with a willingness to invest in communication with scientists and senior leaders, and a passion scientific engagement with colleagues

* A learners mindset with a commitment to personal growth and a drive to broaden technical skills and scientific knowledge

* An ability to think strategically, efficiently manage time and workflows, and work both independently and collaboratively in a cross-functional team environment

* An ability to thrive in a fast-paced, dynamic work environment

**Preferred Qualifications**

* Hands-on experience with LC-MS

* Prior experience with oligonucleotide synthesizers

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