Title Postdoctoral Fellow in Pathology and Laboratory Medicine (Cancer Research and Drug Discovery) Specific Title Appointment Type Postdoctoral Fellow Department IUSM - Pathology & Laboratory Medicine Campus IU School of Medicine Indianapolis Position Summary

The IU School of Medicine has an exciting Postdoctoral Fellow opportunity in the laboratory led by Drs. Magdalena Czader and Chunhai Charlie Hao in the Department of Pathology & Laboratory Medicine. Drs. Czader and Hao collaborate in targeted protein degradation (TPD) for discovery of small-molecule glues as the new anticancer drugs for treatment of leukemia. The team has developed the first small-molecule degraders of SUMO1 protein with the current efforts focusing on the development of SUMO1 degraders as the first-in-class anticancer drugs for treatment of patients diagnosed with cancers including leukemia. The team has developed TPD platform for discovery of small-molecule degraders of other oncoproteins.

This recruit will join the team in development of small molecule degraders as the first-in-class anticancer drugs for treatment of leukemia and other cancers. Experimental approaches being used in the lab include culture, flow cytometry, protein western blots, immunoprecipitation, genomic CRISPR/Cas9, MS/MS proteomic, protein complex structure technologies such as NMR and CRYO-EM and medicinal chemistry in computer-aided and AI-powered drug design and synthesis. The team has cell culture and animal models of various cancers including leukemia samples collected from patients.

The successful candidate will have the opportunity to attend and present his/her work in national and international meetings.

The position is funded by NIH grant and available for an initial appointment of one year, renewable for subsequent years.

Indiana University School of Medicine - As the nation's largest medical school, IUSM is committed to being an institution that not only reflects the diversity of the learners we teach and the patient populations we serve, but also pursues the values of diversity, equity, and inclusion that inform academic excellence. We desire candidates who enhance our representational diversity, as well as those whose work contributes to equitable and inclusive learning and working environments for our students, staff, and faculty. IUSM strives to take an anti-racist stance, regularly evaluating and updating its policies, procedures, and practices to confer equitable opportunities for contribution and advancement for all members of our community. We invite individuals who will join us in our mission to advance racial equity to transform health and wellbeing for all throughout the state of Indiana.

Indianapolis - Indianapolis is the capital and most populous city in the State of Indiana. It is growing economically thanks to a strong corporate base anchored by the life sciences. Indiana is home to one of the largest concentrations of health sciences companies in the nation. Indianapolis has a sophisticated blend of charm and culture with a wonderful balance of business and leisure. The growing residential base is supported by rich amenities and quality of life - the city possesses a variety of professional sports, arts venues, and outdoor recreation areas. Residents of this dynamic city, and surrounding suburbs, enjoy leading educational systems and top-ranked universities, paired with a diverse population. Indianapolis International Airport is a top-ranked international airport, being named "Best Airport in North America" by Airports Council International for many years.

Basic Qualifications

Applicants should have a Ph.D. degree or equivalent in biomedical sciences.

* Strong background and PhD training either in cancer biology, molecular biology, or biochemistry are required.

* Training and research experience in leukemia is a plus, but not necessary.

* Experience in animal studies is not required but it is necessary that candidates can and are willing to work with animals.

* Strong commitment to experimental bench research is expected.

* Naturally collaborative and self-motivated style is necessary to work effectively in this multidisciplinary and integrated team

Department Contact for Questions

Dr. Magdalena B. Czader, mczader@iupui.edu; Dr. Charlie Hao, chunhao@iu.edu; Ms. Sally Atcheson, satcheso@iu.edu.

Additional Qualifications Special Instructions Priority Application Review Deadline Expected Start Date OAA # IUSM-01940-2024