About Us:

Modal Therapeutics is a stealth-stage biotechnology company, dedicated to the discovery and development of innovative and targeted therapies for patients with a wide range of serious and rare diseases. We focus on leveraging biology within the TGFb superfamily, pivotal in regulating diverse cellular processes and tissue remodeling, to tackle the root causes of diseases that lack effective treatments. We are steered by a team of accomplished experts in TGFb biology, protein science, pharmacology, and translational medicine.

Position Overview (Senior Scientist):

We are seeking a highly motivated individual who thrives in a dynamic, fast-paced, team-oriented and collaborative environment to be part of our success in the Cell Biology/Protein Sciences group.

The successful candidate is expected to perform cell-based and in vitro assays using reporter genes and/or gene-expression analyses in cell lines and primary cells. A proven track record of development and execution of novel and established reporter-based assays to screen and evaluate efficacy and mechanism of action of potential therapeutic agents is critical. Experience in establishing and optimizing at least one cell-based reporter assay for candidate screening and lead selection and a willingness to set up additional assay systems is expected. The candidate must have strong written and oral communication skills, be self-motivated, a team player and able to work independently.

Job Responsibilities:

• Culturing of cell lines and primary cells, transfections and perform in vitro assays to evaluate efficacy and mechanism of action of protein therapeutic agents.
• Development and execution of reporter gene assays, cell growth assays, generation and characterization of stable cell lines.
• Familiarity with immune assay, blots, FACS, qPCR, and other in-vitro assays.
• Work with cross functional teams internally and externally to bring research stage molecules to clinical development.
• Independently review scientific literature for advances in the related fields.
• Prepare, present and review scientific presentations for internal/external use.

Basic Qualifications:

• PhD with 2 years or MS degree with 7 years of academic or industrial experience in cell biology.
• Familiarity with TGFb biology and/or prior experience with cell-based assays for selection of potential therapeutic agents is preferred.
• Able to work independently on implementation of experiments under the guidance of senior team members.
• Ability to prioritize responsibilities to meet project deadlines.

To Apply:

Send your resume to careers@modaltx.com We will follow up with you soon.