COMPANY:

At BioCryst, we share a deep commitment to improving the lives of people living with complement-mediated and other rare diseases. For over three decades we’ve been guided by our passion for not settling for “ordinary” in our quest to develop novel medicines. We leverage our expertise in structure-guided drug design to develop first-in-class or best-in-class oral small-molecule and protein therapeutics, led by the efforts of our team of expert scientists in our Discovery Center of Excellence in Birmingham, Alabama. Our global headquarters is in Durham, North Carolina, our European headquarters is in Dublin, Ireland and our employees span the globe across sites in multiple countries. We are proud of our culture of engagement and accountability that rewards people for innovative thinking and achievement of key objectives. For more information, please visit our website at www.biocryst.com or follow us on LinkedIn and Instagram.

JOB SUMMARY:

The Research Scientist, Bioanalytical Chemistry, will be responsible for the ADME screening assays to support lead optimization of small molecules in Discovery. The individual in this role will be responsible for the implementation and operation of in vitro ADME screening assay platforms as well as assist with the expansion of in-house capabilities. This is a unique opportunity to join BioCryst, a company focused on developing life transforming therapies for patients with rare and serious diseases.

ESSENTIAL DUTIES & RESPONSIBILITIES:

• Routinely conducts the existing in vitro ADME assays as well as assisting to develop new ADME assays, such as solubility, permeability, metabolic stability, tissue/protein binding and other related studies to address program needs.
• Designs, plans, and conducts DMPK studies in-house and/or at contract research organizations to support discovery group.
• Supports the in vitro assay study design, sample preparation, sample analysis using LC-MS/MS, and data reporting.
• Perform LC-MS/MS compound tuning, method development, and sample analysis.
• Assists with troubleshooting issues related to assay logistics, planning, execution, and data reporting.
• Implements innovative technologies to improve the screening data quality.
• Prepare, Review/QC and Interpret bioanalytical data and reports from both in house and CROs using Phoenix WinNonlin software.
• Supervise and train the junior chemists in the lab.
• Complies with the Standard Operating Procedures and safety regulations applicable to the job tasks.
• Maintains detailed records and notebooks associated with data reporting and interpretation.
• Proven capability to work in a cross-functional team environment.
• Other duties as assigned.

EXPERIENCE & QUALIFICATIONS:

• Ph.D. in Pharmaceutical Sciences, Pharmacology, Biology, Chemistry, Biochemistry, or related discipline with greater than 2 years of related ADME pharma/biotech experience; or a Master’s/ Bachelor’s degree with >10 years’ experience with in vitro ADME experiments and DMPK projects through academic or industry work.
• Hands-on experience developing and implementing ADME screening assays to support Discovery projects.
• Hands-on experiences with liquid handlers/automation (e.g., Tecan, Hamilton or other automation instrument) is a plus.
• Experiences with liquid chromatography method development: reverse phase, normal phase, ion-pairing, etc. Experiences with chiral separation both analytical and preparation scales preferred.
• Experiences with handling biological matrix, like plasma, blood, urine, cell culture. Cell culture skills are preferred.
• In-depth knowledge in mass spectrometry, hands on experiences in different platforms of LC-MS systems (Waters, Thermo, AB Sciex, Agilent, Shimadzu).
• Familiarity with Phoenix WinNonlin, GastroPlus or ADMET Predictor a plus
• Good working knowledge of ADME principles, demonstrated creativity in assay development.
• Attention to details, effective written, interpersonal and communication skills.
• Strong ability to engage and collaborate across departments with a problem-solving attitude and focus on delivery.
• Ability to work independently in a fast-paced laboratory team environment.
• Ability to meet deadlines, prioritize but remain flexible to adjust to new situations.
• Must be an excellent time manager.

The statements in this position description are intended to describe the general nature and level of work being performed by people assigned to this classification. They are not intended to be construed as an exhaustive list of responsibilities, duties, and skills required of personnel so classified. The manager may assign additional responsibilities and assignments from time to time.

BioCryst is an equal opportunity employer and is committed to providing equal employment opportunities without regard to age, race, religion, sex, sexual orientation, gender identity, national origin, Veterans status, disability and/or other protected class characteristics. Additionally, BioCryst is committed to achieving its business objectives in compliance with all federal, state, and local law.