Sr. Scientist, Protein Engineer

Company Overview

Sarmal, Inc. is a San Diego–based biotechnology company developing next-generation genomics and molecular detection platforms. Our work integrates molecular biology, chemistry, and advanced systems engineering to enable faster, more precise, and more accessible genomic insights.

We are a highly collaborative, R&D-driven team operating in a fast-paced, early-stage environment. Our scientists and engineers work across disciplines to solve complex technical challenges and translate innovation into scalable, real-world applications.

At Sarmal, we value scientific rigor, curiosity, and a builder mindset. We are looking for individuals who are energized by ambiguity, motivated by impact, and excited to help bring breakthrough technologies from concept to reality.

Key Responsibilities

• Design and execute protein engineering strategies (rational design, semi-rational design, and directed evolution)
• Engineer enzymes for improved next generation DNA sequencing performance
• Develop and implement high-throughput screening and selection assays for enzyme variants
• Design and perform enzyme characterization studies using steady-state and pre-steady-state kinetics
• Apply transient-state kinetic methods (e.g., stopped-flow, rapid quench-flow) to resolve catalytic mechanisms and identify rate-limiting steps
• Characterize and compare enzyme mutants using kinetic, biochemical, and biophysical assays to guide engineering decisions
• Quantify enzyme performance metrics including catalytic efficiency (kcat, Km), incorporation rates, fidelity, processivity, and substrate specificity
• Collaborate cross-functionally with computational and assay development teams
• Troubleshoot and optimize protein expression, purification, and assay conditions
• Maintain detailed experimental records and contribute to intellectual property generation

Qualifications

• Deep expertise in enzyme engineering and molecular biology
• Strong foundation in enzyme kinetics, including Michaelis-Menten analysis and transient (pre-steady-state) kinetics
• Hands-on experience characterizing enzyme mutants and interpreting kinetic parameters to guide protein engineering
• Experience with kinetic instrumentation (e.g., stopped-flow, rapid quench-flow, fluorescence-based assays) is highly desirable
• Experience with polymerases or nucleic acid-interacting enzymes preferred
• Strong background in protein expression, purification, and biophysical characterization
• Familiarity with high-throughput screening methods and assay development
• Ability to connect enzyme behavior with system-level performance in sequencing or biochemical workflows
• Knowledge of sequencing technologies is a strong plus
• Strong problem-solving and experimental design skills
• Ability to work in fast-paced startup environments

Education & Industry Experience

• Ph.D. in Biochemistry, Molecular Biology, Protein Engineering, or related field
• 5 years of industry experience in protein engineering and enzymology
• Demonstrated experience in mechanistic enzymology and structure–function analysis of enzyme variants preferred
• Prior experience in NGS or sequencing technologies is a strong plus

Why Join Sarmal

• Work on cutting-edge genomics and molecular detection technologies
• Collaborate with a deeply technical, cross-functional team
• Contribute to foundational platform development at an early stage
• Have visibility into and impact on core technical and strategic decisions
• Help shape the infrastructure, culture, and future direction of the company

Benefits & Perks

Sarmal offers a competitive and comprehensive benefits package, including:

• Medical, dental, and vision coverage
• Company-paid life insurance
• 401(k) retirement plan
• Generous paid time off
• Access to additional voluntary benefits, employee perks, and discount programs

We are committed to supporting the well-being of our employees and providing a strong foundation for both professional and personal success.

California Pay Transparency Statement.

The anticipated salary range for this position is $105,000 – $135,000, depending on experience and qualifications. Final compensation will be determined based on a variety of factors including, but not limited to, location, relevant experience, skill set, and internal equity considerations.

EEO Statement

Sarmal is an equal opportunity employer committed to building a diverse and inclusive workplace. We do not discriminate based on race, color, religion, sex, gender identity or expression, sexual orientation, national origin, ancestry, age, disability, medical condition, genetic information, marital status, veteran status, or any other characteristic protected by applicable federal, state, or local laws.

Reasonable Accommodation Statement

Sarmal is an equal opportunity employer that values diversity and inclusion. We welcome applicants of all backgrounds and consider all qualified candidates in accordance with applicable laws.

Closing Statement

Join us in advancing the next generation of genomic technologies and shaping the future of precision health.