Sr. Scientist, Nucleotide Chemistry

Company Overview

Sarmal, Inc. is a San Diego–based biotechnology company developing next-generation genomics and molecular detection platforms. Our work integrates molecular biology, chemistry, and advanced systems engineering to enable faster, more precise, and more accessible genomic insights.

We are a highly collaborative, R&D-driven team operating in a fast-paced, early-stage environment. Our scientists and engineers work across disciplines to solve complex technical challenges and translate innovation into scalable, real-world applications.

At Sarmal, we value scientific rigor, curiosity, and a builder mindset. We are looking for individuals who are energized by ambiguity, motivated by impact, and excited to help bring breakthrough technologies from concept to reality.

Key Responsibilities

• Synthesize modified nucleosides and nucleotides following established and evolving synthetic routes.
• Purify target compounds by HPLC, flash chromatography, and related methods.
• Characterize products using LC-MS, NMR, UV/Vis spectroscopy, and TLC.
• Maintain thorough laboratory notebooks (electronic or paper) and manage inventories of proprietary compounds.
• Interpret experimental data and present findings and progress at weekly R&D meetings.
• Support troubleshooting, optimization, and scale-up of synthetic processes to improve yield, purity, and throughput.
• Contribute to broader R&D planning and technical strategy discussions as appropriate.

Required Skills & Competencies

• Strong foundation in modern organic chemistry with demonstrated bench experience.
• Background in nucleic acid chemistry—nucleobase, sugar, and phosphate modifications.
• Familiarity with fluorescence, luminescence, and quenching mechanisms is preferred.
• Hands-on proficiency with HPLC, LC-MS, and standard small-molecule analytical techniques.
• Proficiency with analytical methods commonly used in small-molecule synthesis (LC-MS, NMR, UV/Vis, TLC).
• Excellent documentation habits, data analysis skills, and ability to communicate results clearly.
• Comfortable working in a fast-paced startup environment with evolving priorities

Education & Industry Experience Requirements

PhD with 4 years of postdoctoral or industry experience, or MS with 7 years of industry experience, in organic chemistry, nucleic acid chemistry, bioorganic chemistry, or a closely related field

Why Join Sarmal

• Work on cutting-edge genomics and molecular detection technologies
• Collaborate with a deeply technical, cross-functional team
• Contribute to foundational platform development at an early stage
• Have visibility into and impact on core technical and strategic decisions
• Help shape the infrastructure, culture, and future direction of the company

Benefits & Perks

Sarmal offers a competitive and comprehensive benefits package, including:

• Medical, dental, and vision coverage
• Company-paid life insurance
• 401(k) retirement plan
• Generous paid time off
• Access to additional voluntary benefits, employee perks, and discount programs
• We are committed to supporting the well-being of our employees and providing a strong foundation for both professional and personal success.

California Pay Transparency Statement.

The anticipated salary range for this position is $105,000– $135,000, depending on experience and qualifications. Final compensation will be determined based on a variety of factors including, but not limited to, location, relevant experience, skill set, and internal equity considerations.

EEO Statement

Sarmal is an equal opportunity employer committed to building a diverse and inclusive workplace. We do not discriminate based on race, color, religion, sex, gender identity or expression, sexual orientation, national origin, ancestry, age, disability, medical condition, genetic information, marital status, veteran status, or any other characteristic protected by applicable federal, state, or local laws.

Reasonable Accommodation Statement

Sarmal is an equal opportunity employer that values diversity and inclusion. We welcome applicants of all backgrounds and consider all qualified candidates in accordance with applicable laws.

Closing Statement

Join us in advancing the next generation of genomic technologies and shaping the future of precision health.