What are the responsibilities and job description for the NIH Postdoctoral Opportunity in Advancing PBPK Modeling of Fetoplacental Exposure position at National Institutes of Health (NIH)?
This postdoctoral research opportunity is currently available within the National Institutes of Health (NIH), ORIVA (Office of Research Innovation, Validation, and Application). This postdoctoral research opportunity aims to generate quantitative data on placental transfer, permeability, and tissue-specific exposure to improve Physiologically Based Pharmacokinetic (PBPK) models, enabling the translation of in vitro toxicity findings into predictive assessments of human in vivo exposure.
What will I be doing?
- The participant will develop practical skills in advanced cell culture and human-relevant placenta-cardiomyocyte co-culture systems, including experimental design, compound exposure studies, and quantitative assessment of placental transfer and fetal tissue exposure. Training will include laboratory techniques such as permeability and transfer kinetics assays, concentration-response analysis, microscopy, biomarker assessment, and data acquisition using relevant analytical platforms. Training in mitochondria, metabolism and multiomics approaches will also be provided. Under the guidance of a mentor, the participant will also learn how the generated experimental data can be applied in PBPK model parameterization, model refinement, and validation. In addition, the project will strengthen critical thinking, interdisciplinary collaboration, scientific communication, and data interpretation skills within the context of New Approach Methodologies (NAMs) for human based risk assessment.
Why should I apply?
As a participant in a STEM research learning program, you will have the opportunity to explore and understand various NIH support mechanisms and collaborative research initiatives involving NIH. You will be introduced to NIH databases and tools for data analysis, gaining insight into how to identify metrics and key indicators for evaluating programs. Through guided mentorship, you will learn how to assess the outcomes of different types of collaborative research programs, compare their effectiveness, and develop informed recommendations for future initiatives based on available data. This experience is designed to enhance your analytical skills and deepen your understanding of program evaluation in a research-focused environment.
Where will I be located?
Fellows are expected to be fully engaged in-person at Research Triangle Park, NC.
What financial provisions will I receive?
The selected candidates will receive a monthly stipend to help offset living and other expenses during this appointment. Stipend rates are determined by NIH officials and are based on the candidate’s academic and professional background. In addition, NIH may provide a health insurance supplement to cover the monthly premium costs if you elect the ORAU/ORISE health insurance plan, as necessary.
What is the length of the appointment?
The appointment will initially be for one year but may be renewed upon recommendation of NIH and is contingent on the availability of funds, for a total of up to 5 years.
When are selections made?
An initial review of applications will occur on July 1, 2026. Thereafter, applications will be reviewed on a rolling-basis throughout the 2026 calendar year, and selections made as projects for participation become available.
What is the Nature of the Appointment?
This program, administered by ORAU through its contract with the U.S. Department of Energy (DOE) to manage the Oak Ridge Institute for Science and Education (ORISE), was established through an interagency agreement between DOE and the National Institutes of Health (NIH). Participants do not become employees of NIH, DOE, ORISE, nor ORAU, and there are no employment-related benefits.
Salary : $88,000