Manufacturing Chemist 1

Seeking a highly motivated and team-oriented Manufacturing Chemist with experience in organic synthesis to join our Nucleotide Manufacturing group. Manufacture and test components and reagents of moderate to high complexity in a quality manner on standard laboratory equipment by following work instructions and test methods. The candidate must have a strong understanding of purification and analytical techniques used in the manufacture of complex nucleotides and/or oligonucleotides, such as Ion Exchange and Reverse Phase Chromatography. The candidate should have 0- 2 years of chemistry bench experience in synthetic processes.

Responsibilities:

· Synthesize complex organic molecules per established protocols

· HPLC purification and analytical HPLC instrument setup, sample preparation, run execution and data analysis.

· Follow all SOP's and WI's as required by the Quality Management System

· Plan and execute daily work with minimal supervision.

· Generates and analyzes data that leads to decision-making with minimal supervision.

· Executes at a consistently high quality across varying complexities and with a broad array of techniques.

· Operate in compliance with all appropriate regulatory and safety requirements and apply all relevant protocols to work responsibilities.

· Inventory Control of reagents, chemicals and supplies using proper labeling and computerized transactions

· Completes ERP transactions for manufacturing work order processing.

· Work with cross-site and cross-functional teams in R&D, EH&S, Quality Assurance, and Manufacturing Engineering.

· Collaborate with cross-functional teams to assess safety and quality risks and drive improvements where appropriate.

· Perform safety and quality inspections through an established 6S program.

· Operate equipment and conduct tasks in a safe manner, adhering to established guidelines and applicable regulations.

Listed responsibilities are an essential, but not exhaustive list, of the usual duties associated with the position. Changes to individual responsibilities may occur due to business needs.

Requirements:

· 0-2 years of experience in synthetic chemistry processes, purification, and QC analysis of organic molecules.

· Demonstrated ability to follow established protocols in the production of complex organic molecules.

· Solid technical knowledge of synthetic organic chemistry, HPLC methods, manufacturing processes, and manufacturing execution systems.

· High level knowledge with standard laboratory equipment (HPLCs/UPLCs, synthesizers, reactors, rotary evaporators, UV/Vis spectrophotometers, pH meters, etc.).

· Excellent written and verbal communication skills required.

· Basic understanding of equipment/instrument upkeep, calibration, and maintenance policies.

· Familiar with ISO 9001, 13485 and FDA QSR manufacturing standards.

· Knowledge of ERP, EAM, MES and Quality systems (SAP, Camstar, Teamcenter, etc.).

· Basic knowledge of life science industry and experience in DNA analysis methods preferred.

· Experience in lean manufacturing and continuous improvement methodologies preferred.

· High level knowledge of Microsoft Office (Excel, Word, Outlook, etc.)

· Ability to carry up to 40 lbs.

· Bachelor’s degree in biology, Biochemistry or Chemistry, with specialization in synthetic or analytical chemistry preferred.

Preferred Experience/Education/Skills:

Typically requires a Bachelor’s degree and 0-2 years of related experience; or equivalent work experience