Analytical Chemist

Analytical Chemist

Boston, MA

The Analytical Chemist will join the Mass Spectrometry group. In this role, you will be responsible for the end-to-end development, validation, and execution of LC-MS methods across a diverse range of modalities—from primary metabolites and small molecules to complex peptides and intact proteins.

Analytical Chemist Responsibilities:

• Method Development: Design and optimize robust LC-MS/MS methods for the quantification and characterization of small molecules, specialized metabolites, peptides, and proteins.
• Instrumentation: Operate, maintain, and troubleshoot state-of-the-art mass spectrometers, specifically Thermo Orbitrap (Exploris/Lumos) and Triple Quadrupole (TSQ) systems.
• Data Processing: Utilize advanced software (e.g., TraceFinder, Compound Discoverer, Proteome Discoverer, or Skyline) to process complex datasets and deliver actionable insights to project teams.
• Independent Execution: Manage multiple projects simultaneously, from initial experimental design and sample preparation to final data reporting, with minimal supervision.
• Cross-Functional Collaboration: Partner with metabolic engineers, synthetic biologists, and automation engineers to integrate analytical assays into the high-throughput pipelines.

Analytical Chemist Requirements:

• Master’s degree in Analytical Chemistry, Biochemistry, or a related field; or a Bachelors degree with 3 years of relevant industrial experience.
• Hands-on experience with high-resolution accurate mass (HRAM) and MRM/SRM workflows.
• Expertise in various chromatography techniques (RPLC, HILIC, Ion Exchange).
• Familiarity with sample preparation techniques for biological matrices (SPE, SLE, protein precipitation).
• Strong ability to troubleshoot hardware issues and interpret "messy" biological data.
• Excellent written and verbal communication skills, with the ability to present complex analytical findings to non-experts.