Demo

Senior Clinical Trial Manager

Beacon Hill
Cambridge, MA Full Time
POSTED ON 1/6/2026
AVAILABLE BEFORE 2/10/2026

The Senior Clinical Trial Manager (CTM) is responsible for the planning, execution, and oversight of one or more clinical trials across all phases of development. Acting as a key operational lead, this role ensures that studies are delivered on time, within budget, and in compliance with regulatory and quality standards. The Sr. CTM will collaborate cross-functionally, manage external partners, and contribute to process improvements within the Clinical Operations function.

Key Responsibilities:

  • Serve as the primary operational lead for assigned clinical trials, overseeing all aspects of study execution from start-up through close-out.
  • Manage CROs and external vendors to ensure adherence to timelines, budgets, and quality standards.
  • Lead cross-functional study teams to ensure alignment on objectives, deliverables, and risk mitigation strategies.
  • Oversee the development and review of study-related documentation, including protocols, informed consent forms, monitoring plans, and investigator materials.
  • Monitor study progress, including site performance, data quality, and protocol compliance; identify and resolve operational issues proactively.
  • Ensure ongoing inspection readiness and proper maintenance of the Trial Master File.
  • Collaborate with internal stakeholders (e.g., Regulatory, QA, Data Management, Clinical Development) to maintain compliance with GCP, ICH, and applicable global regulations.
  • Support development and implementation of departmental best practices and process improvements.
  • Mentor and provide guidance to junior team members as appropriate.

Required Qualifications:

  • Minimum of 7 years of experience in clinical research, including direct oversight of CROs and vendors.
  • Demonstrated ability to lead cross-functional study teams and manage clinical programs independently.
  • Strong understanding of GCP, ICH guidelines, and regulatory requirements for global clinical trials.
  • Excellent problem-solving, organizational, and analytical skills with a proactive approach to issue resolution.
  • Effective written and verbal communication skills, including experience presenting to cross-functional stakeholders.
  • Ability to manage multiple priorities in a dynamic, fast-paced environment.
  • Proficiency in Microsoft Office and familiarity with project management tools (e.g., MS Project, Smartsheet).
  • Willingness to travel as needed.

Preferred Qualifications:

  • Experience in the biotechnology or pharmaceutical industry preferred.

Education:

  • Bachelor’s degree in life sciences or a related discipline; an advanced degree is a plus.

Salary.com Estimation for Senior Clinical Trial Manager in Cambridge, MA
$111,884 to $142,893
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