Senior Director, US Finance Lead

Join us as we transform immunology and deliver medicines that help autoimmune patients get their lives back. argenx is preparing for multi-dimensional expansion to reach more patients through a rich pipeline of differentiated assets, led by VYVGART, our first-in-class neonatal Fc receptor blocker approved for the treatment of gMG, and with the potential to treat patients across dozens of severe autoimmune diseases.

We are building a new kind of biotech company, one that maintains its roots as a science-based start-up and pushes our commitment to innovate across all corners of our business. We strive to inspire and grow our company, our partnerships, our science, and our people, because when we do, we deliver more for patients.

argenx Vision 2030

argenx has a bold mission to be a global leader in immunology by 2030, with:

• 5 molecules in Phase 3, 10 labeled indications, and 50,000 patients on therapy.
• The US playing a pivotal role, with a growing team (currently ~700, expanding across multiple specialties).
• Q2 2025 US sales of $800 (97% growth from Q2 2024), with continued strong momentum.
  
  
  

A reputation for a unique, empowered team-based model and a strong cultural identity known as the argenx Way.

It is critical that we maintain stability and momentum in delivering commercial results in the US, in the argenx way. This is not a turnaround situation – the operating model is working, the culture is strong and performance is strong.

We are at a crucial inflection point in our leadership journey—transitioning from a hands-on, start-up mindset to a more visionary and strategically driven approach, while continuing to lead with grounded, authentic leadership.

As we navigate this transition, it’s vital that we scale thoughtfully - maintaining the energy and culture that has made us successful. In our start-up phase, leadership meant rolling up our sleeves, taking an active role in day-to-day operations, and responding directly to challenges as they emerged, with a laser focus on delivering results in the US. Moving forward, we need to embrace a broader, more strategic leadership style—one that not only envisions the long-term future for argenx in the US but also contributes to the company’s global 2030 ambition. This critical leadership role must be able to translate this vision into action on the ground, consistently embodying the principles of the argenx Way. This evolution is crucial for our continued momentum and success.

• As the US Finance Lead, this role is pivotal in driving argenx’s innovation mission by ensuring the financial health, strategic allocation of resources, and sustainable growth of the US business
• The Finance Lead is directly responsible for overseeing financial planning and analysis, optimizing the US P&L, and providing clear, actionable insights that guide commercial and medical affairs strategy. This leader works in close partnership with cross-functional teams to advance the innovation agenda from early discovery through commercialization, acting as a key business partner to accelerate the company's vision
• The Finance Lead must embody enterprise leadership, fostering alignment among all US teams and connecting the financial strategy to the global “one company, one team, one plan” vision. As a cultural ambassador for the argenx Way, this leader champions operational excellence, transparency, and the scaling of best practices, ensuring that as the organization grows, it maintains its distinctive energy, strong culture, and commitment to impactful innovation
  
  
  

Roles And Responsibilities

Financial Leadership & Strategic Planning

• Play a leadership role in finance to support argenx’s innovation mission in the US by ensuring the financial health, strategic allocation of resources, and sustainable growth of the US business
• Responsible for all aspects of financial planning and analysis, financial reporting, budget and forecasts preparation. S/he will play a critical role in the financial planning process focusing on value creation and aligning resources with strategic priorities
• S/he will be actively involved in the launch plan projects including providing financial support to all key functional areas critical to the launch plan
• Key member in the finance team to lead innovation, for example developing a state-of-the-art planning and management reporting process to forecast the US financial results and deliver timely insights to the business
• Prepare annual budgets and quarterly forecasts in partnership with the HQ Finance team, reporting variances and recommending actions as needed
• Developed and maintain a long-range planning (LRP) and Sales and operating model for multiple indications
• Lead monthly management accounts to enable real-time decisions as well as play a leading role in transition to real-time customer focused dashboards and AI supported insights to the commercial business and leaders
• Developed and maintain the inventory management for stable supply of all products to serve patients. This includes forecasting and reporting of supply needs for the US
• Drive the development, enhancement, and maintenance of complex financial models, including long-range planning (LRP) for bookings, revenue, expenses, P&L, and cash flow management
• Partner with Accounting team to support the accounting processes, including A/R, A/P, GL, analytical projects, and revenue recognition, to ensure both accuracy and the integrity of local and corporate financial records
  
  
  

Internal Control, Audit, and Compliance

• Collaborate with the Controller and Internal Control Lead to review, update, and document business processes within the COSO framework, maintaining robust internal controls and effective SOX compliance
• Partner with the Head of Tax to ensure timely and accurate management of all local, state, and federal government reporting requirements, including tax filings and local tax risk monitoring
  
  
  

Business Partnership & Operational Excellence

• Serve as a key partner to cross-functional teams, driving the US innovation agenda from early discovery through commercialization, and ensuring the translation of strategic vision into actionable results
• Lead and mentor a team of Financial Analysts, providing financial leadership, coaching, and analytical support
• Execute special projects as needed, driving operational efficiencies and business scaling while maintaining the distinctive argenx culture and energy
  
  
  

Leadership Attributes and Cultural Fit

• Visionary, strategic, and entrepreneurial mindset with the ability to inspire, empower, and motivate teams across functions and geographies
• Servant leadership—supporting others to achieve shared goals, with a ‘high challenge and high support’ philosophy
• Embodies the argenx Way—patient-centricity, humility, resilience, authenticity, collaboration, and a learning mindset
• Inclusive, non-hierarchical leader who integrates diverse talents, values mutual trust, and “walks the talk” as a cultural ambassador
• Balances a hands-on approach for financial operations with a strategic, long-term vision for commercialization and organizational growth
  
  
  

Experience, Education And Qualifications

• Extensive experience in finance business partnering supporting US biotech organizations
• Advanced degree in Accounting, Economics, or a related field.
• Minimum of 10 years of comprehensive accounting and finance experience, with significant time as Finance Director/Controller or equivalent
• Strong modeling, analytical, and critical thinking skills; detail-oriented and structured in approach
• Excellent IT skills, including experience with ERP systems (Oracle preferred) and Microsoft Office suite
• Demonstrated ability to thrive under pressure and tight deadlines, with a proven autonomous, hands-on work style
• Ability to scale thoughtfully, preserving the energy and core culture that drives success at argenx
• Connects financial strategy to the “one company, one team, one plan” vision, bridging US operations with global ambitions
• Models curiosity, a commitment to learning, and a passion for serving patients as the ultimate purpose
  
  
  

At argenx, all applicants are welcomed in an inclusive environment. They will receive equal consideration for employment without discrimination on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability, or any other applicable legally protected characteristics. argenx is proud to be an equal opportunity employer.

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