Sr. Downstream Processing Technician

Job Title: Downstream Processing Technician III

Job Description

This role offers an opportunity to advance your manufacturing career in a world-class scientific environment focused on producing large-scale biologics and chemistry-based pharmaceutical components. As a Downstream Processing Technician III, you support the flawless execution of manufacturing batch records, work instructions, and standard operating procedures (SOPs) within a cGMP-regulated cleanroom setting. You work closely with a team of skilled professionals to maintain suites, equipment, and documentation to strict quality standards, ensuring products are manufactured safely, consistently, and right the first time.

Responsibilities

• Execute manufacturing batch records, work instructions, and SOPs with a strong focus on proactive, right-first-time performance.
• Assist with batch record reconciliation to ensure complete, accurate, and compliant documentation.
• Support all departmental functions, including maintaining the manufacturing suite, supplies, equipment, logbooks, and data in accordance with site SOPs and policies.
• Document all activities in compliance with cGMP requirements, including completing daily record reviews, tasks, and database entries.
• Perform document reviews and revisions to maintain accurate and up-to-date procedures and records.
• Actively participate in shift exchanges, one-on-one discussions, and team meetings, and attend additional meetings as needed to support area needs and continuous improvement initiatives.
• Engage in lean activities and contribute ideas to improve process efficiency, quality, and safety.
• Support quality investigations by answering questions, providing feedback, and suggesting process improvements.
• Practice and promote safe work habits and adhere to all safety procedures and guidelines within the cleanroom and production areas.
• Critically evaluate processes, applying foresight and forward thinking to anticipate issues and propose solutions.
• Interpret production schedules and prioritize tasks accordingly to meet manufacturing timelines and output goals.
• Apply aseptic techniques and cleanroom practices to maintain product integrity and prevent contamination.
• Handle materials, equipment, and components safely, including lifting up to 25 pounds and working on your feet for most of the shift.
• Contribute as a subject matter resource on downstream processing steps as experience and knowledge increase.

Essential Skills

• Bachelor’s degree in a STEM-related field (such as science, technology, engineering, or mathematics).
• Minimum of 2 years of work experience in manufacturing, operations, production, laboratory, or a closely related field.
• Foundational knowledge of cGMP practices, aseptic techniques, or chemical concepts (or the ability to quickly learn and apply them).
• Ability to execute and follow detailed manufacturing batch records, work instructions, and SOPs accurately.
• Strong attention to detail with a commitment to right-first-time execution and high-quality documentation.
• Ability to document activities clearly and accurately to meet cGMP and regulatory requirements.
• Capability to interpret production schedules and prioritize work in a fast-paced environment.
• Comfort working in a cleanroom environment, including meeting all gowning and hygiene requirements.
• Physical ability to lift a minimum of 25 pounds independently.
• Ability to stand for approximately 80% of the shift.
• Willingness and ability to work rotating 12-hour shifts, including nights and weekends, according to the defined schedule.

Additional Skills & Qualifications

• Experience (6 months or more) in a GMP-regulated environment and with aseptic techniques is preferred.
• Experience in a cGMP environment combined with a 4-year STEM degree is preferred.
• Bachelor’s degree in a science discipline with exposure to aseptic technique, chemistry, HPLC, pharmaceutical industry processes, or chromatography is highly valued.
• Familiarity with downstream processing steps and the ability to serve as a subject matter expert is preferred.
• Experience working in cleanroom or aseptic suites, including proper gowning and aseptic behavior.
• Knowledge of laboratory techniques and concepts related to chemistry and pharmaceutical manufacturing.
• Strong communication skills to actively provide feedback, participate in meetings, and support quality investigations.
• Demonstrated ability to work effectively in a team environment and collaborate across shifts.
• Interest in large-scale biological and chemical pharmaceutical operations, particularly in producing proteins and biologics used in therapies such as those for autoimmune diseases.

Work Environment

You work in a cleanroom and aseptic suite environment that requires strict adherence to gowning and hygiene procedures. You must be willing to wear full gowning, including a bodysuit, gloves, hair and beard nets, face covers, and safety glasses. To maintain cleanroom integrity, you cannot wear makeup, jewelry, nail polish, cologne or perfume, scented lotions, or scented hair care products while in the controlled areas. You must be able to meet cleanroom gowning requirements, including wearing Tyvek garments and Nitrile and/or Latex gloves. The role involves standing for approximately 80% of your shift and lifting at least 25 pounds independently. The position includes structured training: you train Monday through Friday on a day schedule for the first 4–6 weeks, focusing on SOPs and safety, before transitioning to 12-hour shifts for continued on-the-job training. Starting in July, the schedule moves to 10-hour shifts (40 hours per week) on a 3-2-2-2-3 pattern, with a strong likelihood of working a second shift (approximately 2:00 p.m. to 12:00 a.m.). The standard pattern includes rotating 12-hour shifts, working 7 days over a 2-week period (for example, Week 1: work Monday–Tuesday, off Wednesday–Thursday, work Friday–Sunday; Week 2: off Monday–Tuesday, work Wednesday–Thursday, off Friday–Sunday). Both day and night shift opportunities may be available, including night shifts from approximately 6:00 p.m. to 6:45 a.m. You operate within a highly regulated, safety-focused environment that supports large-scale biologics and pharmaceutical production, offering exposure to advanced manufacturing technologies and processes. #

This is a Contract to Hire position based out of Saint Louis, MO.

The pay range for this position is $28.00 - $32.20/hr.

Eligibility requirements apply to some benefits and may depend on your job classification and length of employment. Benefits are subject to change and may be subject to specific elections, plan, or program terms. If eligible, the benefits available for this temporary role may include the following:
• Medical, dental & vision
• Critical Illness, Accident, and Hospital
• 401(k) Retirement Plan – Pre-tax and Roth post-tax contributions available
• Life Insurance (Voluntary Life & AD&D for the employee and dependents)
• Short and long-term disability
• Health Spending Account (HSA)
• Transportation benefits
• Employee Assistance Program
• Time Off/Leave (PTO, Vacation or Sick Leave)

This is a fully onsite position in Saint Louis,MO.

This position is anticipated to close on May 10, 2026.

Diversity, Equity & Inclusion

At Actalent, diversity and inclusion are a bridge towards the equity and success of our people. DE&I is embedded into our culture through:

• Hiring diverse talent
• Maintaining an inclusive environment through persistent self-reflection
• Building a culture of care, engagement, and recognition with clear outcomes
• Ensuring growth opportunities for our people

Actalent is an equal opportunity employer.

About Actalent

Actalent is a global leader in engineering and sciences services. For more than 40 years, we’ve helped visionary companies advance their goals. Headquartered in the United States, our teams span 150 offices across North America, EMEA, and APAC—with four delivery centers in India led by 1,000 extraordinary employees who connect their passion with purpose every day.

Our Bangalore, Hyderabad, Pune, and Chennai delivery centers are hubs of engineering expertise, with core capabilities in mechanical and electrical engineering, systems and software, and manufacturing engineering. Our teams deliver work across multiple industries including transportation, consumer and industrial products, and life sciences. We serve more than 4,500 clients, including many Fortune 500 brands. Learn more about how we can work together at actalentservices.com.

Salary : $28 - $32