The Contract Research Associate (RA) I, High throughput process development (HTPD), provides support to the High Throughput Process Automation group through the deployment of robotic stations and automation workflows to execute experiments for the development and optimization of downstream processes delivering adeno-associated virus (AAV) vectors. The role employs their scientific expertise and experience to generate reliable and reproducible data with thorough documentation supporting early research and process development activities and scale-up operations. The RA I is expected to work closely with the Upstream Process Development, Downstream Process Development, Analytical Development and Vector Core groups to foster a collaborative environment delivering sound and robust manufacturing processes for AAV vectors.
The successful candidate will participate in the development and execution of High Throughput experimentation workflows including the development of scalable processes for AAV production and supporting analytical methods. The role will involve the deployment of robotic platforms and pertinent computational tools to execute experiments and report results in a timely fashion while working together with members of the HTPA team.
Primary Responsibilities Include:
* Operate laboratory automation equipment (e.g., Tecan, Hamilton) to support high throughput process development screening experiments.
* Execute HTPD experiments with AAV vectors involving high throughput chromatography techniques.
* Perform analytical testing to support HTPD experiments and participate in development of new assays as needed.
* Participate in lab management activities including the preparation of laboratory reagents and solutions, and the maintenance of key lab instrumentation and critical laboratory materials.
* Analyze, collate, track, and report data back to stakeholders.
* Maintain records and test results following good manufacturing practices (GMP).
* Work independently and efficiently.
* Document work clearly and perform tests accurately.
* Communicate effectively with stakeholders.
* Adhere to safety protocols and use knowledge of Good Laboratory Practices (GLPs) to advance projects under rapidly shifting priorities and timelines.
Desired Education and Skills:
* B.S. degree in Bioengineering, chemical/biochemical engineering, biology, biochemistry, or related discipline, with 1-3 years of related experience.
* Basic laboratory skills, with at least one year of laboratory experience.
* Experience in downstream processing techniques for production of biologics and viral vectors (AAV, Lenti-).
* Experience in basic biochemistry laboratory techniques such as qRT-PCR, SDS-PAGE, Western blot, ELISA, etc.
* Experience working with laboratory automation or advanced computer-controlled laboratory equipment, such as chromatography workstations (e.g. Akta), or robotic liquid-handlers (e.g. Tecan or Hamilton).
* Highly computer literate. Capable of quickly learning and adapting to new computer programs. Experience using formulas and linking spreadsheets in Excel.
* Experience in programming/coding (e.g. equipment software, Visual Basic, C , MatLab, or Python programming) is considered a plus.
* Strong computer, scientific, and organizational skills.
* Excellent communication (oral and written) and attention to detail.
* Ability to work independently and as part of a team, self-motivation, adaptability, and a positive attitude.
* Ability to learn new techniques, perform multiple tasks simultaneously, keep accurate records, follow instructions, and comply with company policies.
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