The Translational Medicine department at Genentech informs clinical development of Client personalized therapeutics through establishment of biomarker strategies aimed to study biological pathways driving disease and by characterizing the mechanism of action of Client therapeutics. As a key member of the biomarker mass spectrometry laboratory, the ideal candidate will utilize mass spectrometry to explore Client biomarker hypotheses, assist in streamlining existing workflows, and help to drive innovation within the group through improved LC-MS/MS method development. Experience in clinical proteomics and clinical sample processing is required. Hands-on experience with maintaining LC and MS instrumentation is also required.
•PhD in Analytical Chemistry, Biochemistry, or Biotechnology and successful postdoctoral research training in a related field
•Minimum of 6 years of hands-on experience with liquid chromatography and tandem mass spectrometry (LC-MS/MS) approaches, and have excellent troubleshooting capabilities
•Strong analytical background with fundamentals in assay development, system suitability, and method evaluation
•Experience with discovery proteomics approaches (TMT, DIA-MS, SWATH, etc.) and corresponding data analysis tools
•Knowledge of sample preparation techniques for analysis of biomarkers and other mediators from biological fluids (e.g. plasma, CSF, urine, stool, etc.)
•A proven ability to analyze and visualize complex datasets using tools like MSstats, Spotfire, R, or Skyline and experience with standard instrument software such as Analyst or Xcalibur
•In addition, the candidate should have excellent communication, presentation, and interpersonal skills, be able to work independently as well as in a team environment, and be willing and eager to learn and train others on new technologies