SUMMARY:

Generation Bio is seeking an energetic and highly motivated molecular biologist with broad expertise in utilizing CRISPR/Cas systems for therapeutic applications. The ideal candidate will have experience developing and executing assays to characterize on- and off-target editing profiles. This role is very cross functional with key interactions between bioinformatics, cell biology, translational biology & formulation teams.

RESPONSIBILITIES: 

• Develop, optimize, and execute assays to characterize off-target editing events (biased and unbiased)
• Support on-target editing analysis workflow
• Assist development of technical strategy in collaboration with broader team
• Work independently with guidance and support from manager and broader molecular biology team
• Work with cross-functional teammates including translational biology, cell biology, and bioinformatics

QUALIFICATIONS:

• Bachelors or Master of Science in Molecular Biology, Biochemistry, Microbiology or related field
• A minimum of 2 years of industry experience in a relevant field is preferred
• Hands-on experience with experimental off-target editing analysis methods (e.g., GUIDE-seq, SITE-seq, digenome-seq, etc.)
• Hands-on experience with experimental on-target editing analysis methods (e.g., Sanger sequencing, NGS)
• Experience with automated liquid handling systems is a plus
• Expertise with mammalian cell culture is a plus, especially primary cells (e.g. HSCs)
• Experience and knowledge of multiple gene-editing systems
• Fluency and extensive hands-on experience with molecular biology and synthetic biology techniques with a focus on application to mammalian systems

POSITION: Full-Time, Exempt