Neurodegenerative diseases are one of the largest medical challenges of our time. Denali Therapeutics is a biotechnology company based in South San Francisco, California that is dedicated to defeating neurodegenerative diseases through rigorous therapeutic discovery and development. Denali is founded on the collaboration of leading scientists, industry experts, and investors who share the vision that scientific discovery energetically applied to translational medicine is the key to delivering effective therapies to patients.
The Opportunity
We are currently seeking an outstanding Associate Scientist to join our Preclinical Translational Sciences group. The primary function of this group is to leverage the use of animal models for biomarker discovery as well as establishing PK/PD relationships with Denali's therapeutic candidates. The role will be critical in supporting the execution of all in vivo study activities.
Responsibilities (included but not limited to the following):

• Serve as the operational lead on multiple programs to contribute to the timely completion and success of research projects. This includes coordinating in vivo study logistics, study preparation (i.e. tube labeling), sample management, and execution of the study
• Perform routine drug dosing in mice and rats by various routes of administration (IV, PO, IP, SQ, RO, IT) and in life sample collections (i.e. blood collection via submental, tail vein, jugular, saphenous, etc. and urine collection)
• Experience with in life rodent surgeries to include stereotaxic intracerebroventricular injections, pump implantation, etc.
• Perform necropsy procedures including terminal blood collection by cardiac puncture, perfusion of rodents and gross anatomical tissue harvesting
• Think creatively about ways to leverage novel techniques or tools for in vivo use
• Experience with various wet lab techniques desirable (i.e., tissue homogenizations, tissue sectioning/histology) as well as clear and concise communication of data
• Maintain accurate and complete laboratory records in a timely manner
• Collaborate with scientists across the organization to enable timely and thorough data generation
• Responsibilities require a work schedule that may include working outside of normal work hours, to meet business demands such as weekends/Holidays to support dosing (on a rotating schedule)

Requirements

• BS or MS in Biology or relevant field with additional 4-6 years of relevant work experience, preferably in a pharmaceutical / biotech setting
• Extensive hands-on experience working with both mice and rats
• Must have strong work ethic, proficiency in animal welfare and overall knowledge for animal care and use
• Independent, highly organized, great attention to detail, ability to multi-task, and a strong desire to work in a highly collaborative and fast paced environment
• Excellent interpersonal and communication skills
• Experience with computer applications such as MS Excel, MS Word, MS PowerPoint
• Knowledge in some of the following wet lab technologies desirable: qRT-PCR, BCA

Denali is committed to its core company value of Unity by creating a diverse and inclusive environment. We are proud to be an equal opportunity employer and do not discriminate against any employee or applicant for employment because of race, color, sex, age, national origin, religion, sexual orientation, gender identity and/or expression, status as a veteran, basis of disability, or any other federal, state, or local protected class.
Salary Range: $100,000 to $126,667. Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. Denali offers a competitive total rewards package, which includes a 401k, healthcare coverage, ESPP and a broad range of other benefits. Learn more at https://www.denalitherapeutics.com/careers
*This compensation and benefits information is based on Denali's good faith estimate as of the date of publication and may be modified in the future.
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