Demo

Manager, Human Resources Business Partner

Twist Bioscience
South San Francisco, CA Full Time
POSTED ON 12/30/2025
AVAILABLE BEFORE 3/27/2026
Twist is seeking a dedicated and experienced Manager, Human Resources Business Partner (HRBP) to provide hands-on HR support and consulting to our rapidly expanding Global Commercial organization (Sales, Marketing, and Customer Support). This role reports to the Senior Vice President, Human Resources and will work in close partnership with our entire HR team. As we scale our commercial team in response to strong customer adoption of our NGS and Synthesis products, this manager will be key to enabling their success. We are looking for an individual who is ready to roll up their sleeves and expertly handle day-to-day people decisions while beginning to step into a more strategic partnership role with our global commercial leaders.

What You'll Be Doing

Business Partnership & Consulting

  • Trusted Advisor: Serve as a primary HR contact, partnering with commercial leaders to enable their success by providing expertise on routine people issues and strategies.
  • Problem Solving: Bring practical and effective solutions that address the immediate needs of the commercial department while considering the broader implications for Twist and our HR strategies.
  • Leadership Enablement: Apply a broad HR skill set to coach managers and evolve the department's effectiveness. This includes, but is not limited to, performance management, talent assessment, organizational design and development, workforce planning, and supporting change management initiatives.

HR Operations & Compliance

  • Process Execution: Execute global and local HR processes (e.g., talent management, succession planning, annual performance reviews, development planning, compensation planning) ensuring alignment to and execution of established Twist-wide policies and procedures.
  • Proactive Issue Resolution: Help identify and solve talent issues at the manager level before they affect the business (e.g., HiPo retention efforts, addressing poor performance, skill-gap identification).
  • Recruitment Support: Contribute to the assessment and selection when recruiting for commercial team members, including key leaders and other critical positions.
  • Compliance: Ensure all HR practices within the area of responsibility comply with legislative, regulatory requirements, standards, and other relevant policies in both US and EU business areas, following ISO 13485 requirements.
  • Employee Relations (ER): Triage and respond to employee relations issues (e.g., employee concerns or complaints, worker’s compensation cases) and serve as the go-to HR team member for the commercial team's questions and concerns.
  • Global Adaptation: Implement our HR strategies and projects with sensitivity for and adaptation to local cultural business norms to support our global workforce.

What You'll Bring to the Team

  • 5 years of progressively responsible HR experience, with at least 2 years in an HR Business Partner role supporting commercial/sales teams.
  • Industry Knowledge: Experience in the Biotech or Pharmaceutical industry is a strong asset.
  • Experience applying a range of HR skills, from leadership enablement to talent assessment.
  • JMust have the ability to make effective recommendations to resolve problems or issues, using judgment that is consistent with standards, practices, policies, procedures, regulation, or government law in both US and EU business areas.
  • Ability to objectively coach employees and management through complex and difficult issues to drive us toward a high-performing organization.
  • Team player with a strong ethical orientation, proven track record of high performance, strong aptitude for listening, collaborating, and problem-solving.
  • Demonstrates cultural humility to ensure success when partnering and enabling our diverse workforce, including our global leaders.
  • Strong business acumen, excellent verbal/written communication skills, and the ability to organize and prioritize work.
  • Ability to travel domestically and internationally as required to attend commercial team meetings (~15-20%).

Preferred Qualifications

  • Previous work experience in a non-HR role at some point during your career (i.e., bringing direct, applied business experience to your HR career).
  • Background in employment law and other government compliance regulations.
  • Experience supporting employees and leaders in Asia-Pacific Regions.

The base cash compensation for this California-based role is below. In addition to base salary, this role is eligible for bonus, equity, and a generous benefits package. Final compensation amounts are determined by multiple factors, including candidate skill, experience, expertise, and location and may vary from the amount listed above. Compensation may be different in other locations.

San Francisco Bay Area Pay Range

$145,000 - $186,000 USD

Salary : $145,000 - $186,000

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