Demo

Sr IT System Administrator

Twist Bioscience
South San Francisco, CA Full Time
POSTED ON 12/31/2025
AVAILABLE BEFORE 1/30/2026
Sr IT Systems Administrator (in SSF, CA)

Job Description:

Twist is seeking a System Administrator who is responsible for endpoint engineering efforts and activities. This role is responsible for building, testing, and deploying OS and application packages and images throughout the organization. This user software lifecycle continues with evaluating, testing, and operating of endpoint management and security tools. This role is tightly integrated with our IT Service Desk Staff and expected to be an escalation point for endpoint issues and requests. Your work will directly have an impact on the day-to-day working user experiences.

Job Responsibilities:

  • Manage OS images and applications via SDLC build/test/deploy/monitor methodology using Jamf, InTune, or similar
  • Develop and manage OS and software deployment tools, including JAMF, InTune, MDT, SCCM, InstallShield, etc.
  • Experience managing large scale, unattended upgrades for both local and remote users, such as one-touch deployments
  • Document the library of Endpoint software (current and legacy)
  • Experience with maintaining the security posture of endpoints, including endpoint encryption, DLP and endpoint monitoring systems
  • Experience with client backup and restore solutions
  • Experience with IAM solutions, SSO/SAML, and identity integrations into AD
  • Experience managing systems with Intune/AzureAD on-premise (Group Policy, SCCM and Active Directory architecture and administration)
  • Experience integrating SaaS applications into the software stack, providing data sync, automations, and integrations where appropriate and adding value
  • Experience automating tasks (software deployment and configuration,) using powershell or other scripting language.
  • Investigate new and emerging technologies for possible inclusion in the end user computing environment
  • Experience running projects from end-to-end - including requirements gathering, documentation, test plan development and conducting UATs, change management and post production support
  • Perform cost/benefit analysis and able to produce executive level briefings regarding technologies, solutions and trends
  • Be a technical escalation point for Endpoint Software Issues and work within ITIL ticketing systems.
  • Create, update, and maintain IT related documentation for support staff and users, including self-help solutions and runbooks.

Qualifications and Requirements:

  • BA/BS degree in CS, MIS, or other equivalent IT field or equivalent experience
  • 8 years in end-user support and endpoint system management
  • 4-6 years expert experience in AD/GPO administration
  • 4 years advanced experience in SCCM / MDT / WSUS tools
  • 4 years of application packaging and repackaging for Windows and OSX
  • 4 years responsible for SaaS application administration and integrations
  • Understanding of TCP/IP networks, DHCP, and DNS as it applies to end user connections
  • Uses empirical troubleshooting techniques to troubleshoot and identify root causes
  • Must be solutions oriented; and a strong self-starter with initiative and flexibility
  • Must be flexible business needs and scheduling. Some after-hours work may be required
  • Exceptional customer service orientation using listening, consulting, problem identification and resolution skills
  • Excellent verbal and written communication skills are required
  • Demonstrated ability to work effectively as part of a team
  • Familiarity with ITIL concepts for service management a plus, especially Problem and Change management
  • Genuine willingness and aptitude to mentor less senior team members

Technical Certifications Desired:

  • JAMF 100,200,300
  • MCSA, MCSE, MCP, MCDST a plus,
  • ITIL Foundations
  • Project Management

About Twist Bioscience

Twist Bioscience synthesizes genes from scratch, known as “writing” DNA. Just as children learn to both read and write, the next phase of development for the genomics revolution is the ability to write DNA.

At Twist Bioscience, we work in service of people who are changing the world for the better. In fields such as health care, agriculture, industrial chemicals and data storage, our unique silicon-based DNA Synthesis Platform provides precision at a scale that is otherwise unavailable to our customers.

Twist Bioscience Corporation is an Equal Opportunity Employer. Twist Bioscience Corporation provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, genetic characteristics, or any other category protected by law.

The base cash compensation for this California-based role is below. In addition to base salary, this role is eligible for bonus, equity, and a generous benefits package. Final compensation amounts are determined by multiple factors, including candidate skill, experience, expertise, and location and may vary from the amount listed above. Compensation may be different in other locations.

San Francisco Bay Area Pay Range

$129,900 - $163,200 USD

Salary : $129,900 - $163,200

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