Research Assistant III | Functional Genomics

Research Assistant III | Functional Genomics

Genetically Diverse Cardiomyocyte Screening Program

New York, New York

JAX/NYSCF Global Stem Cell Array

JAX/NYSCF is seeking a Research Assistant III to join the Functional Genomics team as part of the NYSCF Global Stem Cell Array, a robotic system that automates both iPSC derivation, gene editing, and downstream differentiations.

The Research Assistant III will contribute to an innovative project centered on phenotyping cardiomyocytes derived from genetically diverse human induced pluripotent stem cell (hiPSC) lines. This work aims to uncover the genetic basis of cardiotoxic responses and to advance predictive models of cardiovascular health through high-throughput functional screening, transcriptomics, and metabolomics.

The project is highly collaborative, involving multidisciplinary teams across several institutions. The primary focus of the work you'll do at JAX/NYSCF is developing automated protocols for the derivation/culture of iPSC-derived cardiomyocytes, drug testing, and sample preparation for downstream analyses, including imaging and single-cell sequencing.

We want candidates with extensive expertise in human pluripotent stem cell culture, directed differentiation into cardiomyocytes, and functional assays. Experience with cell culture automation (including liquid handling systems) or high-throughput assays is a major plus.

This role offers a unique opportunity to work with state-of-the-art screening technologies and automated platforms while contributing to impactful translational research in cardiac safety pharmacology and personalized medicine.

As a Research Assistant III on the Functional Genomics team, you will:

• Execute experiments to advance a high-throughput iPSC-derived cardiomyocyte platform designed by a senior Scientist/mentor
• Culture and expand iPSCs, generate iPSC-derived cardiomyocytes, and assess cardiomyocyte quality using automated liquid handling systems
• Apply scientific knowledge and experience to monitor, troubleshoot, and refine experimental workflows in real time
• Conduct literature reviews to identify and propose innovative experimental methods, procedures, or technologies
• Contribute to project planning by preparing budgets, timelines, and resource estimates for supplies and equipment
• Feels comfortable with multiple concurrent project components
• Evaluate and document results and maintain compliance with regulatory standards
• Coordinate with external partners to explore new research opportunities
• Foster a collaborative environment by sharing expertise and demonstrating openness to learning from others

Minimal requirements

• BSc/MSc 6 years of academic or industry experience in Cell Biology, Molecular Biology, Biomedical Engineering, or a related discipline.
• Experience with induced pluripotent stem cells or cardiomyocytes/ iPSC-derived cardiomyocytes.
• Strong communication skills, with the ability to clearly explain research findings and methodologies in both written and verbal formats, as well as effectively discuss, troubleshoot, and resolve experimental challenges with team members and collaborators.
• Ability to follow protocols accurately.
• Excellent documentation and data management practices.

Preferred experience:

• Experience in differentiation of iPSC culture in cardiovascular lineages.
• Exposure to automated cell culture systems (liquid handlers)
• Electrophysiology experience is a plus
• Flow cytometry

Pay Range: $49,163 - $82,311

About JAX:

The Jackson Laboratory is an independent, nonprofit biomedical research institution with a National Cancer Institute-designated Cancer Center and nearly 3,000 employees in locations across the United States (Maine, Connecticut, California),Japan andChina. Its mission is to discover precise genomic solutions for disease and empower the global biomedical community in the shared quest to improve human health.

Founded in 1929, JAX applies over nine decades of expertise in genetics to increase understanding of human disease, advancing treatments and cures for cancer, neurological and immune disorders, diabetes, aging and heart disease. It models and interprets genomic complexity, integrates basic research with clinical application, educates current and future scientists, and provides critical data, tools and services to the global biomedical community. For more information, please visitwww.jax.org.

EEO Statement:

The Jackson Laboratory provides equal employment opportunities to all employees and applicants for employment in all job classifications without regard to race, color, religion, age, mental disability, physical disability, medical condition, gender, sexual orientation, genetic information, ancestry, marital status, national origin, veteran status, and other classifications protected by applicable state and local non-discrimination laws.