What are the responsibilities and job description for the Molecular and Cellular Biologist position at Tech Observer?
Contract: 12 Months with the possibility of extension
Summary:
The Molecular and Cellular Biologist will support efforts to apply multi-omics & systems biology approaches to improve mammalian cell culture performance for the production of recombinant proteins.
Job Responsibilities:
- Design and execute molecular and cellular biology experiments involving the transfection, passaging, and sampling of CHO cell cultures to generate substrate for multi-omics analyses.
- Design and execute experiments to examine gene copies, transcript levels, protein folding, assembly, trafficking, secretion, and degradation.
- Analyze and interpret data using statistical, bioinformatics, and pathway-analysis tools.
- Document findings and prepare technical reports, presentations, and manuscripts.
- Collaborate with cell-line development scientists, bioprocess engineers, analytical scientists, and computational biologists.
- Comply with laboratory safety and data-integrity requirements.
Skills:
- Strong experimental design, analytical thinking, and problem-solving skills.
- Proficiency in mammalian cell culture and molecular biology techniques (e.g. aseptic technique, cell transfection, DNA/RNA extraction, PCR, qPCR, electrophoresis, molecular cloning, DNA/RNA sequencing, immunoblotting, FACS, microscopy).
- Familiarity with multi-omics study design, bioinformatics, statistical analysis, and systems biology.
- Strong understanding of molecular cell biology fundamentals including DNA replication, transcription, translation, proteostasis, metabolism, cellular stress mechanisms, and their relation to recombinant protein production.
- Effective written and verbal communication.
- Ability to work well and collaboratively within multidisciplinary teams.
- Strong attention to experimental rigor, documentation, reproducibility, and scientific integrity.
Education/Experience:
- Bachelor’s or master’s degree in molecular biology, cell biology, biochemistry, biotechnology, bioengineering, systems biology, or a related field required.
- Zero to two years of relevant laboratory or biotechnology-industry experience.
- Experience with mammalian and/or CHO cell culture, antibody production, multi-omics technologies, molecular perturbation methods, and regulated laboratory environments is preferred.