What are the responsibilities and job description for the Scientist position at SPECTRAFORCE?
Position Title: Scientist
Work Location: South San Francisco, CA 94080
Assignment Duration: 06 Months
Work Arrangement: Onsite
Position Summary: The Quantitative, Translational ADME Sciences (QTAS) department at our organization is seeking a highly motivated scientist to join the Biologics bioanalysis, characterization, and proteomics group.
The main function of this position is to develop and implement LC/MS (liquid chromatography/mass spectrometry)-based bioanalysis and in vitro characterization assays for novel biologics entities.
Key Responsibilities:
- Operate and maintain LC/MS instruments to generate high-quality experimental data.
- Perform affinity purification of therapeutic proteins (including but not limited to monoclonal and bispecific antibodies, antibody drug conjugates, antibody-siRNA conjugates, and fusion proteins) from biological matrices.
- Analyze data and maintain detailed, accurate and comprehensive study documentation in electronic laboratory notebooks.
- Facilitate assay optimization and implementation to ensure laboratory capacity and data quality.
- Communicate data interpretation internally and externally.
Qualifications & Experience:
- Degree in chemistry, pharmacology or other related fields. BS/MS with 1 year of LC-MS (QQQ) experience or a fresh PhD with the right LC-MS experience, in a pharmaceutical industry setting with a focus on mass spectrometry.
- Highly motivated, self-driven and results-oriented with excellent communication and presentation skills; capable of working both as a team player and individual contributor.
- Prior industry experience in drug discovery/development is preferred. In-depth understanding of PK, TK and PK/PD studies and corresponding bioanalytical assays as well as in vitro characterization assays is highly desired.
- Hands-on experience with QQQ (SCIEX), qTOF (Agilent, Bruker, SCIEX) and/or Orbitrap (Thermo) mass spectrometers is highly desired.
- Hands-on experience with automated liquid handling systems is highly desired.
- Hands-on experience with oligonucleotide analysis is highly desired.
- Degree in chemistry, pharmacology or other related fields.
- Highly motivated, self-driven and results-oriented with excellent communication and presentation skills; capable of working both as a team player and individual contributor
- Experience on routine LC/MS-based bioanalysis to support in vivo PK, TK, and PK/PD studies