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Executive Director of Bioinformatics

Soufflé Therapeutics
Watertown, MA Full Time
POSTED ON 8/2/2026
AVAILABLE BEFORE 8/31/2026

Soufflé Therapeutics | Executive Director, Bioinformatics | Job Description


Soufflé Therapeutics is a biotech company focusing on the cell-type specific delivery of genetic medicines. It's team of driven scientists is making a mark in delivery of oligonucleotides to extrahepatic tissues. We thrive in a purpose-building lab and office space in Watertown. Come and join us in our quest!


Position Summary:

Soufflé is seeking an Executive Director, Bioinformatics to define and lead our multi-year bioinformatics and data science strategy across research, translational science, and clinical development. This backfill is an opportunity to bring additional breadth and AI/ML leadership as we scale, championing responsible AI/ML integration and governance while building a team that turns diverse data into decisions.


Key Responsibilities

  • Work with R&D leadership to define a multi-year bioinformatics and data science strategy across research, translational science, and clinical development
  • Lead a team that translates diverse data into insights and decisions
  • Champion responsible AI/ML integration and governance frameworks, and mechanisms to prioritize high-impact projects
  • Build a team and culture that engages and partners with stakeholders to bring new workflows, initiatives, and case studies to realization
  • Act as a collaborative, highly integrative team player across the organization


What Success Looks Like

  • In 3 months: A growth gameplan aligned for the next 2-3 years, with a plan in place for key AI/ML rollout and governance initiatives; set priorities and communicate for the next 3-6 months.
  • In 6 months: Successful system roll-outs, with a strong queue of high-value use cases; able to see clear early success with first roll out cases
  • In 12 months: Strategy set for the next stage of growth


Qualifications — Required

  • 12 years of relevant bioinformatics/data science experience, including 4 years in a functional leadership role
  • Strong change management and stakeholder engagement skills, with a customer-oriented working style
  • Experience defining and leading data science/bioinformatics strategy across research and clinical development functions


Qualifications — Preferred

  • Experience with multi-omic data analysis and integration, machine learning/AI methodologies, and data pipeline and dashboard development


Education

  • Ph.D. in Bioinformatics, Computational Biology, Biostatistics, Computer Science, or a related field


This is an onsite position in Watertown, MA (US) with flexibility as needed for collaboration and external engagements.


At Soufflé Therapeutics, we are intentional about building an equitable culture. How we treat our people is reflective of this focus. We are an Equal Opportunity Employer. We celebrate diversity and are committed to creating an inclusive environment for all employees.


Salary.com Estimation for Executive Director of Bioinformatics in Watertown, MA
$256,998 to $314,251
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