Senior Associate Scientist II, Protein Sciences

Senior Associate Scientist II, Protein Sciences – Solid Biosciences

Charlestown, MA

Solid Biosciences is a precision genetic medicine company focused on advancing a portfolio of gene therapy candidates targeting rare neuromuscular and cardiac diseases, including Duchenne muscular dystrophy (Duchenne), Friedreich’s ataxia (FA), catecholaminergic polymorphic ventricular tachycardia (CPVT), TNNT2-mediated dilated cardiomyopathy, BAG3-mediated dilated cardiomyopathy, and additional fatal, genetic cardiac diseases. We are advancing a diverse pipeline and delivery platform in the pursuit of uniting experts in science, technology, disease management, and care.

Patient-focused and founded by those directly impacted by Duchenne, Solid’s mission is to improve the daily lives of patients living with devastating rare diseases.

We are seeking a skilled and motivated associate scientist to join the Molecular Therapeutics team to purify AAV libraries and to define the mechanism of transduction of selected capsids. The ideal candidate will have a strong background in protein science including protein binding assays, protein structure, and cell biology.

This role will be based in Solid’s Corporate Headquarters located in Hood Park in Charlestown, MA and is a primarily onsite position.

Key Position Responsibilities

• Optimize methods for production and isolation of AAV capsid libraries using automated liquid handlers such as Tecan
• In vitro AAV transduction experiments in normal and CRISPr KO cells
• Protein binding and inhibition experiments
• Contribute to modelling of protein structures
• Collaborate within the molecular therapeutics team and across the R&D organization including computational biologists, analytical development, and process development
• Communicate findings and insights to stakeholders through reports, presentations, and visualizations.
  
  

Experience Requirements

• Bachelor of Science with 3-5 years of industry experience, or MS with 0-3 years of experience in protein science research
• Experience with AAV and/or antibody production and drug development
• Strong technical skills in protein biochemistry and cell biology to define the mechanism of AAV transduction
• Proficiency in computing include Geneious, BLAST, Ensembl, NCBI, Uniprot, USCS, GTEx, Microsoft, PRISM statistics program
• Strong problem-solving skills and the ability to work independently and collaboratively.
• Excellent communication and presentation skills.
  
  

Compensation

The base compensation range for this role is: $100,000.00 - $125,000.00

Base salary offered is determined through an internal analysis utilizing a combination of factors including, but not limited to, relevant skills & experience, job location, and internal equity.

Regular employees are eligible to receive both short-term and long-term incentives, including cash bonus and equity incentive opportunities, designed to reward individual performance and align incentives to Solid’s long term company performance.

Benefits And Solid Advantages

At Solid Biosciences we offer a highly competitive total rewards and benefits package, intended to support all aspects of our employees’ lives and well-being. Additionally, for those employees working onsite at our Hood Park Headquarters, we offer a variety of onsite resources to support those working in our offices.

• Competitive Health and Dental programs with flexible plan offerings, including FSA and HSA programs
• 401(k) program participation with competitive company matched contributions
• Eligibility to participate in Solid’s Employee Stock Purchase Plan
• Mobile phone subsidy for eligible employees
• Tuition Reimbursement
• Vision Coverage
• Life Insurance
• Voluntary Pet Insurance
• Employee Discount Program on Travel, Entertainment, and Services
• Employee Assistance Programs
• Daily Subsidized Lunch Delivery (onsite @ Hood Park)
• Free Onsite Full-Service Gym (onsite @ Hood Park)
• Employee Parking (onsite @ Hood Park)
• 12 Observed Holidays and a winter shut down
• 15-day PTO Policy and a 40-hour rollover YoY
• 40-hour Sick Policy
• 8 Hour Floating Holiday