Senior Research Associate, Protein Sciences

Ampersand Biomedicines is a Flagship Pioneering company on a mission to transform patients’ lives with programmed medicines that work precisely where needed, and nowhere else. We’re building a collaborative, mission-driven team that thrives in a fast-paced environment and shares a genuine desire to make a difference. We ACT our values by working with Agility to adapt and deliver impact, leading with Compassion to put people first, and practicing Transparency to build trust through openness, clarity, and integrity. At Ampersand, employees are encouraged to explore breakthrough science, take chances, support one another, and contribute ideas and perspectives openly.

The Role

Ampersand is currently seeking a highly motivated scientist with a background in protein sciences to contribute to the discovery and development of AND-Body™ Therapeutics. The role will focus on antibody engineering, protein production and purification, and biochemical and biophysical characterization to support biologic therapeutics development.

Key Responsibilities

• Support the research team in protein production and characterization across multiple research programs.
• Perform protein and antibody production activities, including cell culture, transfection, and protein purification.
• Execute protein and antibody biophysical characterization using techniques such as SDS-PAGE, aSEC, BLI, SPR, DSF, DSC, cIEF and other emerging tools.
• Optimize critical parameters for binding assays, including AlphaLISA and HTRF.
• Perform ELISA assays to measure serum antibody titers and functional biomarkers.
• Collaborate with team leads on antibody campaign efforts to support antibody discovery programs.
• Maintain clear, effective communication and strong collaboration with cross-functional colleagues.
• Ensure high standards of data integrity and maintain accurate and well-documented research records in electronic laboratory notebook (ELN).
  
  

Required Professional Experience & Qualifications

• B.S. or M.S. in Biology, Biochemistry, or a related scientific discipline.
• Minimum of 2 years of relevant laboratory experience in an academic or industrial setting.
• Experience in construct design, plasmid prep, and protein/nucleic acid sequence analysis.
• Hands-on experience in protein expression and purification, including production in E. coli, mammalian, and/or cell-free systems.
• Strong theoretical knowledge and hands-on experience in chromatography, including FPLC (ÄKTA) and HPLC using SEC, HIC, and IEX chromatography columns.
• Practical experience with multiple biochemical and biophysical techniques, including SDS-PAGE, Western blotting, BLI, SPR, DSF, DSC, MS, AlphaLISA, and HTRF.
• Ability to analyze and interpret complex datasets using statistical software (e.g. Excel, GraphPad Prism).
• Excellent data record keeping and organization.
• Strong written and verbal communication skills, with the ability to clearly interpret data and present results to project teams.
  
  

Preferred Professional Experience & Qualifications

• Experience with high-throughput protein production and characterization
• Experience with membrane protein production and characterization
• Knowledge of protein structure and structure-based analysis tools.
• Publication record and experience with scientific conference posters and presentations
• Industry experience as a Protein Sciences team member within a pharmaceutical or biotechnology company
  
  

Ampersand Biomedicines is committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.

Recruitment & Staffing Agencies: Ampersand Biomedicines does not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to Ampersand and/or Flagship Pioneering or its employees is strictly prohibited unless contacted directly by Ampersand or Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of Ampersand and FSP, and Ampersand/FSP will not owe any referral or other fees with respect thereto.

The salary range for this role is $81,000.00 - $107,300.00. Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. Ampersand currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Ampersand’s good faith estimate as of the date of publication and may be modified in the future.