What are the responsibilities and job description for the Sr Associate Scientist, Cell Culture position at Proclinical Staffing?
Sr Associate Scientist - Contract - Cambridge, MA
Play a key role in advancing and optimizing autologous cell‑based therapy processes from bench to manufacturing.
Proclinical is seeking a Senior Associate Scientist to join our client's Cellular Process Development team supporting the development and optimization of autologous cell‑based therapy processes. This role requires flexibility, efficiency, and the ability to thrive in a collaborative, fast‑paced laboratory environment. The successful candidate will contribute to process understanding, experimental execution, and continuous improvement across cell therapy workflows.
Primary Responsibilities:
The successful candidate will focus on advancing process understanding and driving robust improvements in autologous immune cell manufacturing processes. The role leverages multidisciplinary tools and methods to support cellular drug product development and the evaluation of new technologies.
Skills & Requirements:
- Bachelor's degree in a science‑related field (Biology, Biochemistry, Biotechnology, or similar).
- Hands‑on experience with aseptic cell culture and primary human immune cell culture.
- Working knowledge of cell therapy bioreactor systems and scale‑up concepts.
- Proficiency in flow cytometry and cell counting methodologies.
- Strong organizational skills with the ability to work effectively in fast‑paced, cross‑functional environments.
The Sr Associate Scientist's responsibilities will be:
- Independently design, execute, and manage laboratory experiments involving:
- Primary human immune cell isolation (e.g., PBMCs)
- Cell activation, genetic modification (e.g., viral transduction)
- Cell expansion and cryopreservation
- Apply statistical and data visualization techniques to analyze results, assess process performance, and draw data‑driven conclusions.
- Support process development and scale‑up efforts to translate benchtop cell culture workflows into manufacturing‑relevant processes.
- Perform multi‑color flow cytometry and cell‑based assays to characterize cell therapy drug products and evaluate process performance.
- Maintain accurate, complete, and compliant laboratory documentation in alignment with internal policies and regulatory expectations.
- Contribute to daily laboratory operations, continuous improvement initiatives, and feasibility assessments for new process concepts.
- Assist with laboratory equipment upkeep, safety practices, and general lab organization to maintain an efficient working environment.
If you are having difficulty in applying or if you have any questions, please contact Mike Raletz at m.raletz@proclinical.com.
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