Senior Scientist – Antibody Display Technology and HTP Screening

The heart of Prellis Bio’s strategy is the combination of novel, cutting edge methods in machine learning, biology at scale and next gen antibody discovery that address long-standing industry-wide problems in the drug development pipeline. Prellis Biologics uses proprietary technology to 3D print human lymph node organoids enabling the rapid & diverse discovery of human antibody therapeutic candidates for a range of applications. To drive this forward, we are assembling an incredible team of discovery biologists, computational scientists, and protein scientists who want to make a difference to this important problem.

Position Summary

We are seeking a Senior Scientist – Antibody Display Technology and HTP Screening to grow our high-throughput (HTP) screening capability and accelerate our biotherapeutic discovery efforts. You will be responsible for:

• Developing and implementing mammalian display or other HTP screening platforms identify high affinity antibody candidates.
• Driving strategic innovation by shaping the future of our EXIS and AI/ML discovery platforms.

The ideal candidate will thrive in a dynamic environment and play a critical role in delivering life-changing therapeutics.

Responsibilities

• Design, develop, and optimize in vitro display platforms to integrate synthetic or EXIS immune libraries.
• Apply HTP selection and screening (e.g., FACS, cell-based assays, microfluidics) to identify binders with improved affinity, functional or biophysical properties.
• Design, strategize, and execute on engineering requests to further develop and optimize candidates.
• Collaborate with interdisciplinary teams, including Protein Science, AI/ML, and NGS groups.
• Drive platform innovation through agile, hypothesis-driven research and rapid iteration.

Qualifications

• PhD or MS in Molecular Biology, Biochemical engineering, or Immunology with 3 (PhD) or 5 (MS) years of relevant experience.
• Demonstrated experience in developing and utilizing mammalian display and one or more platforms (e.g. yeast/phage display, CHO secretion) for HTP screening of antibody libraries.
• Experience with antibody library design and construction.
• Familiarity with antibody sequence analysis tools (Geneious, PipeBio).
• Experience with flow cytometry panning and iQue cell binding screening.
• Strong understanding of therapeutic antibody discovery process.
• Strong organizational skills, attention to detail, and ability to drive multiple projects.
• Demonstrated experience in collaborating across various scientific disciplines in a dynamic environment.

Bonus Experience

• Working knowledge in binding, functional or developability assays for antibody characterization.
• Familiarity with structural biology tools (e.g., PyMOL, Chimera, AlphaFold).
• Keen interest in AI/ML driven discovery, protein optimization, and attribute prediction.
• Experience in antigen design and preparation.

What you can expect of us

As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we’ll support your journey every step of the way.

The expected annual salary range for this role in the U.S. is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.

Application deadline

Prellis does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.

Prellis Bio is an equal opportunity employer. All applicants will be considered for employment without attention to race, color, religion, sex, sexual orientation, gender identity, national origin, veteran or disability status.

We believe diversity, equity, and inclusion need to be at the foundation of our culture. We work hard to bring together diverse teams–grounded in a wide range of expertise and life experiences–and work even harder to ensure those teams thrive in inclusive, growth-oriented environments supported by equitable company and team practices. All candidates can expect equitable treatment, respect, and fairness throughout the interview process.