Senior/Principal Scientist – Next Generation Sequencing

The heart of Prellis Bio's strategy is the combination of novel, cutting edge methods in machine learning, biology at scale and next gen antibody discovery that address long-standing industry-wide problems in the drug development pipeline. Prellis Biologics uses proprietary technology to 3D print human lymph node organoids enabling the rapid & diverse discovery of human antibody therapeutic candidates for a range of applications. To drive this forward, we are assembling an incredible team of discovery biologists, computational scientists, and protein scientists who want to make a difference to this important problem.

Position Summary

We are seeking a highly motivated
Senior/Principal Scientist – Next Generation Sequencing (NGS)
to drive our biotherapeutic discovery efforts and technological advancements. This pivotal role involves:

• Implementing cutting-edge NGS and molecular techniques for rapid discovery of novo antibody candidates.
• Driving strategic innovation by shaping the future of our discovery platforms.
• Collaborating across functions and providing effective leadership and mentorship within the NGS team.

The ideal candidate will thrive in a dynamic environment and play a critical role in delivering life-changing therapeutics.

Responsibilities

• Lead the strategic planning and execution of NGS-enabled discovery campaigns.
• Drive capability building and technology innovation (e.g., CITE-Seq, automation).
• Partner with the bioinformatician to ensure effective dissemination of experimental results, driving data-informed decision-making.
• Collaborate with Data Science team to establish robust data pipelines and support AI/ML projects.
• Leverage cross-functional collaboration to accelerate lead identification.
• Empower team members through mentorship to achieve measurable capability improvement.

Qualifications

• Ph.D. and relevant postdoctoral experience in Molecular Biology and Immunology, and 3 years (Senior Scientist) or 5 years (Principal Scientist) of relevant experience with expanding scientific capabilities and professional development.
• Demonstrated experience in leading high-performing teams (2-3 people).
• Broad knowledge in therapeutic antibody discovery pipeline with hands-on experience in antibody sequencing technologies (e.g., single B cells, bulk BCR repertoire, 10xGenomics).
• Deep knowledge in antibody repertoire biology and sequence attributes.
• Exceptional interpersonal and communication skills in a collaborative environment.
• Strong organizational skills, attention to detail, and ability to drive multiple projects.
• Demonstrated experience in collaborating across various scientific disciplines in a dynamic environment.

Bonus Experience

• Familiarity with automated liquid handlers or high-throughput molecular biology workflows.
• Working knowledge in display-based discovery techniques.
• Keen interest in AI/ML driven discovery, protein optimization, and attribute prediction.

About Prellis

Prellis Biologics is a pre-IPO biotech located in Berkeley CA with a team-oriented, inclusive, and family-friendly culture. Our growing pipeline target high unmet patient needs across therapeutics including metabolic, inflammation, and oncology disease. Prellis has raised funding from top investors, including Celesta, Khosla Ventures, SOSV, & Avidity Partners.

What you can expect of us

As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we'll support your journey every step of the way.

Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.

In addition to the base salary, Prellis offers compelling benefits based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include:

• A competitive employee benefits package, including group medical, dental and vision coverage, life and disability insurance, flexible spending accounts an a 401(k) plan
• Stock-based long term incentives
• Holiday package including a 1 week winter shutdown
• Flexible work models, including remote and hybrid working arrangements, where possible

Application deadline

Prellis does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.

Prellis Bio is an equal opportunity employer. All applicants will be considered for employment without attention to race, color, religion, sex, sexual orientation, gender identity, national origin, veteran or disability status.

We believe diversity, equity, and inclusion need to be at the foundation of our culture. We work hard to bring together diverse teams–grounded in a wide range of expertise and life experiences–and work even harder to ensure those teams thrive in inclusive, growth-oriented environments supported by equitable company and team practices. All candidates can expect equitable treatment, respect, and fairness throughout the interview process.