Scientist

Worcester, MA, 1-year contract

The Biologics CMC Developability team is an integral part of the Biologics CMC Drug Product Development Org. The Biologics CMC Developability team is responsible for- (1) the identification of biophysical- and chemical liabilities in discovery-stage biologic drug candidates to guide lead selection, and (2) for characterization of the key CMC attributes important for biologic drug development. We have an exciting opportunity for a motivated scientist to join the Biologics CMC Developability team.

Key Responsibilities:

• Perform in-depth LC-MS based characterization of therapeutic biologic molecules and their post-translational modifications.

• Conduct liquid chromatography-based characterization of biologic drug candidates (size exclusion, ion exchange, and reverse phase).

• Execute experimental protocols, collect results, and perform data analysis carefully and independently.

• Maintain excellent documentation of work including electronic lab notebook and protocols.

• Prepare and deliver concise scientific presentations of experimental results.

• Oversee maintenance of key laboratory equipment and routine laboratory operations.

• Build strong relationships with other team members and across groups.

• Understand and adhere to corporate standards regarding code of conduct, safety, and documentation compliance.

Qualifications:

• BS or MS in Biochemistry, Biology, Chemistry (or equivalent, e.g., Chemical Engineering, Pharmaceutical Sciences) with 3-5 (BS) or 1-2 years (MS), or Ph.D. with 0 years of biopharmaceutical industry experience.

• Hands-on experience with protein mass-spectrometry (subunit analysis, peptide mapping, disulfide mapping) and data processing is required.

• Experience with liquid chromatography methods commonly used for characterization of biologic proteins is required.

• Experience with liquid handling robots and their programming would be highly beneficial.

• Demonstrated track record of independent thinking, creativity, and scientific accomplishment.

• Highly responsible and self-motivated. Skills to plan and conduct experiments with high quality and timely deliverables. Able to perform data analysis using MS Excel & GraphPad.

• Team player with excellent collaboration and communication skills.