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Senior Director of Manufacturing

Piper Companies
Durham, NC Full Time
POSTED ON 11/18/2025 CLOSED ON 12/17/2025

What are the responsibilities and job description for the Senior Director of Manufacturing position at Piper Companies?

Piper Companies is seeking a Sr. Director of Manufacturing for a leading global CDMO located in Durham, North Carolina (NC). The Sr. Director of Manufacturing will be responsible for overseeing large-scale GMP manufacturing operations, ensuring compliance with regulatory standards, and driving operational excellence across multiple production lines. This is a hybrid position in Durham, NC.

Responsibilities of the Sr. Director of Manufacturing:

  • Lead all GMP manufacturing operations, including production planning, scheduling, and execution.
  • Ensure compliance with cGMP, FDA, and global regulatory standards across all processes.
  • Drive continuous improvement initiatives to enhance efficiency, reduce costs, and maintain quality.
  • Partner with Quality, Supply Chain, and Engineering to achieve production and client goals.
  • Mentor and develop manufacturing leadership teams, promoting a culture of safety and compliance.
  • Oversee technology transfer, scale-up, and validation for new products and processes.
  • Monitor KPIs and deliver performance reports to senior leadership for strategic decision-making.

Qualifications for the Sr. Director of Manufacturing:

  • 10 years of experience in pharmaceutical or biologics manufacturing, with at least 5 years in a leadership role.
  • Strong background and knowledge of aseptic processing, biologics, or sterile drug product manufacturing.
  • Proven track record in managing large teams and complex manufacturing operations.
  • Experience in a CDMO environment highly preferred.

Compensation for the Sr. Director of Manufacturing:

  • Salary Range: Starting at $200,000/year

This job opens for applications on 11/12/2025. Applications for this job will be accepted for at least 30 days from the posting date.

Keywords: Senior Director of Manufacturing, GMP Manufacturing Leadership, Pharmaceutical Manufacturing, Biologics Manufacturing, Aseptic Processing, Fill-Finish Operations, Continuous Improvement, Lean Manufacturing, Operational Excellence, Technology Transfer, Scale-Up and Commercialization, CDMO Manufacturing, FDA Compliance, cGMP Compliance, Quality Systems, Supply Chain Integration, Manufacturing Strategy, Process Optimization, Leadership and Team Development, Manufacturing Sciences & Technology (MS&T), Biopharma Manufacturing, Sterile Drug Product Manufacturing, Validation and Qualification, Manufacturing Operations Management, KPI Performance, Risk Mitigation, Manufacturing Site Leadership, Pharmaceutical Operations Director, RTP Manufacturing Jobs, North Carolina Biomanufacturing

Salary.com Estimation for Senior Director of Manufacturing in Durham, NC
$137,500 to $168,129
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