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Principal Project Manager

Pharmaceutical Company
South San Francisco, CA Contractor
POSTED ON 4/23/2026
AVAILABLE BEFORE 5/21/2026

Job Title: Principal Project Manager

Location: South San Francisco, California (Onsite)

Duration: 8 Months

Job Type: Contract on W2

Workplace Type: Onsite


Job Description

We are seeking an experienced Principal Project Manager to lead complex initiatives across the development lifecycle, from concept and design through post-approval activities. This role will support Device Development - Business Operations & Compliance Support in a highly matrixed and cross-functional environment.

Key Responsibilities

Project Management & Execution

  • Translate device strategy into actionable, inspection-ready Design & Development Plans
  • Manage end-to-end projects across development pipelines, line extensions, and technology initiatives
  • Drive team performance, decision-making, issue resolution, and cross-functional collaboration
  • Lead governance processes, stage-gates, and committee reviews

Compliance & Quality Management

  • Implement, maintain, and continuously improve Quality Management Systems (QMS)
  • Manage DHF and controlled documentation repositories for compliance and completeness
  • Lead audit readiness for internal audits and health authority inspections
  • Oversee CAPA and remediation activities

Operations & Continuous Improvement

  • Identify risks and implement mitigation strategies
  • Improve business processes, PM tools, and operating models
  • Forecast resources, monitor budgets, and track project costs

Required Qualifications

  • Bachelor’s degree in Engineering, Technical Discipline, or related field
  • 12 years in Pharmaceutical or Medical Device industry
  • 5–6 years in Devices or Combination Products
  • Strong experience in drug/device development and commercialization
  • Deep knowledge of EU MDR, FDA 21 CFR Parts 210, 211, 820, and ISO 13485
  • Strong project management expertise, PMP preferred
  • Executive presence with ability to work independently

Additional Details

  • Onsite role in South San Francisco
  • Minimal travel, 1–2 times annually
  • Ability to support global hours, including 7 AM - 10 AM Pacific when needed
  • Interview Process: 2 Rounds (Virtual Onsite Panel)

Salary : $65 - $95

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