Sr. Bioinformatics Scientist – Novel Cell Free DNA Applications

Personalis, Inc. is a leader in advanced genomics for precision oncology. NeXT Personal is an ultra-sensitive, tumor-informed, WGS-based liquid biopsy assay designed to detect minimal residual disease (MRD) and cancer recurrence. It leverages whole-genome sequencing of a patient's tumor and matched normal samples to create personalized panel of up to 1,800 somatic variants, enabling the detection of circulating tumor DNA (ctDNA) at very low levels (down to ~1-3 PPM) in blood samples. To enable cancer and population sequencing, Personalis' Clinical Laboratory was built with a focus on clinical accuracy, quality, big data, scale, and efficiency.

Days Onsite: Monday & Tuesday

Summary:

The Senior Bioinformatics Scientist will work with a world-class, dynamic team of bioinformatics scientists, software engineers, and laboratory scientists, developing, testing, and applying cutting-edge cell-free and solid tumor cancer genomics products. Further, the Senior Bioinformatics Scientist will work closely with our clinical evidence generation teams, applying our cell-free technology solutions to large cancer patient cohorts and profiling patient response to therapy with our cfDNA platforms. This position will directly contribute to a new generation of genomics-based precision-medicine products for profiling MRD, ctDNA dynamics, and patient response to treatment. Our products are used by pharma, biotech, hospitals, and clinicians for managing patient treatment and therapeutic selection.

Responsibilities:

• Design and develop novel cell-free technologies and products
• Collaborate closely with laboratory scientists to design experiments to develop and evaluate novel applications for cell-free DNA assays
• Draw on deep experience with genomics and statistics to model and improve performance of cell-free assays and features
• Synthesize large datasets to develop and evaluate new biological and technological hypotheses
• Partner with the clinical evidence generation team to ensure the applicability and evaluate the performance of novel assays or feature improvements
• Maintain a strong working knowledge of literature covering technological developments in the cell-free DNA and liquid biopsy space
• Publish results and present at conferences in exciting areas, including cell-free DNA and cancer genomics

Requirements:

• Advanced degree (Ph.D.) in bioinformatics, genomics, or a related field
• Extensive experience with cancer genomics
• Extensive experience with somatic mutational detection and filtering
• Experience with cancer liquid biopsy analysis
• Proficiency in the application of statistical methods to genomic applications
• Proficiency with at least one common programming language (e.g., Python, R)
• A track record of designing and implementing experimental approaches to confirm and elaborate upon findings from complex projects
• Experience publishing and presenting scientific results

The hiring range for this position is $155,000 to $190,000 per year, which may factor in various geographic regions. The base pay actually offered will take into account internal equity and also may vary depending on the candidate’s geographic region, job-related knowledge, skills, and experience among other factors. Our full-time regular positions also include an annual performance-based bonus (or a sales incentive plan) and long-term incentive units (equity) provided as part of our compensation package, in addition to a full range of medical, financial, and/or other benefits, dependent on the level and position offered.

Personalis is an equal opportunity employer and is committed to the full inclusion of all individuals. As part of this commitment, Personalis will ensure that persons with disabilities are provided with reasonable accommodations. If you need an accommodation to participate in the job application or interview process, to perform essential job functions, and/or to receive other benefits and privileges of employment, please let your recruiter know, if/when they contacts you.

Protecting Our Candidates: At Personalis, we value your security. Please note that all official correspondence from our team will come exclusively from @personalis.com email addresses. We will never ask for personal financial information or conduct interviews over text or chat platforms. If you receive a suspicious request, it is likely a scam. We are committed to a safe recruitment experience and actively work with authorities to investigate and prosecute cyber crimes targeting our community.

Personalis offers a competitive compensation package and benefits including medical, dental, vision, 401(k) match, ESPP, tuition reimbursement, sick/vacation time, commuter benefits/ EV charging stations, onsite gym, and wellness benefits. (For US only, benefits in other countries may vary.) 

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