Demo

Sr. Payroll Analyst

personalisinc
Fremont, CA Full Time
POSTED ON 4/6/2026
AVAILABLE BEFORE 6/4/2026

Personalis, Inc. is a leader in advanced cancer genomics for enabling the next generation of precision cancer therapies and diagnostics. The Personalis NeXT Platform® is designed to adapt to the complex and evolving understanding of cancer, providing its biopharmaceutical customers and clinicians with information on all of the approximately 20,000 human genes, together with the immune system, from a single tissue sample. In population sequencing, Personalis operates one of the largest sequencing operations globally and is currently the sole sequencing provider to Veterans Affairs' Million Veteran Program. To enable cancer and population sequencing, Personalis' Clinical Laboratory was built with a focus on clinical accuracy, quality, big data, scale and efficiency. The laboratory is GxP-aligned as well as Clinical Laboratory Improvement Amendments of 1988-certified and College of American Pathologists-accredited.

Days Onsite: Monday & Tuesday (Hybrid)

Summary:

The Sr. Payroll Analyst is responsible for processing the Company’s payroll using the ADP platform on a regular basis in accordance with the Company’s policy and ensuring accurate reflection of payroll data in the financial statements. This position will work closely with Accounting and Human Resources team members to perform the scope of work, and provide exceptional service to the entire employee base. The position will also flex to support other areas in accounting, as needed.

Responsibilities:

  • Responsible for full cycle processing of all payroll functions including, time & attendance, time-off, security master, reporting, and workflow administration for all U.S. employees.
  • Prepare accounting transactions, including journal entries for bi-weekly payroll/payroll accruals and reconcile payroll related accounts monthly.
  • Prepare payroll account reconciliations and flux commentaries for financial statement close review.
  • Enforce payroll policies and procedures to ensure proper internal controls and efficient processes in compliance with SOX 404 requirements.
  • Manage new state registrations for withholding tax, SUI (state unemployment insurance) and any applicable local taxes.
  • Review and audit employee 401(k) contributions as well as make contribution deposits to 3rd party 401(k) administrator in a timely manner.
  • Work closely with HR team to ensure employee new hires, terminations, LOA’s, and other changes that affect payroll are processed accurately and timely.
  • Review voluntary deductions including medical benefits, FSA, ESPP, 401(k) contributions and loans as well as involuntary deductions, such as garnishments.
  • Enter equity related income for NQ exercises and RSU releases. Reconcile YTD taxes to payroll accounting system.
  • Responds to employee questions and addresses any payroll issues/updates/edits required.
  • Ensure timely and accurate W-2 preparation at the end of each calendar year.
  • Creating and run payroll related reports as required for interdepartmental and cross functional charges and reference.
  • Other ad-hoc related tasks as required

Qualifications - Required:

  • Bachelor’s degree in Accounting, Finance, Business Administration, or related field.
  • 5-8 years of progressive payroll experience 
  • Experience with supporting month-end close for payroll related accounts and account reconciliations
  • Multi-state payroll experience with ADP Workforce Now and other related systems such as Time & Attendance using time card and Time Off module etc.
  • Great team player, flexible and able to adapt to a changing environment. Ability to multi-task and meet challenges with resourcefulness, effectively handle competing demands, take responsibility for fulfillment of obligations and willing to put in extra time as necessary to complete work and achieve goals.  
  • Attention to detail with a high-quality focus as well as timeliness.
  • Excellent communication and interpersonal skills.

Qualifications - Preferred:

  • Experience working with U.S. public company with between 100 to 500 employees

The hiring range for this position is $98,000 to $115,000 per year, which may factor in various geographic regions. The base pay actually offered will take into account internal equity and also may vary depending on the candidate’s geographic region, job-related knowledge, skills, and experience among other factors. Our full-time regular positions also include an annual performance-based bonus (or a sales incentive plan) and long-term incentive units (equity) provided as part of our compensation package, in addition to a full range of medical, financial, and/or other benefits, dependent on the level and position offered.

Personalis is an equal opportunity employer and is committed to the full inclusion of all individuals. As part of this commitment, Personalis will ensure that persons with disabilities are provided with reasonable accommodations. If you need an accommodation to participate in the job application or interview process, to perform essential job functions, and/or to receive other benefits and privileges of employment, please let your recruiter know, if/when they contacts you.

Protecting Our Candidates: At Personalis, we value your security. Please note that all official correspondence from our team will come exclusively from @personalis.com email addresses. We will never ask for personal financial information or conduct interviews over text or chat platforms. If you receive a suspicious request, it is likely a scam. We are committed to a safe recruitment experience and actively work with authorities to investigate and prosecute cyber crimes targeting our community.

Personalis is an Equal Opportunity Employer/Minorities/Females/Veterans/Disabilities. Personalis offers a competitive compensation package and benefits including medical, dental, vision, 401(k) match, ESPP, tuition reimbursement, sick/vacation time, commuter benefits/ EV charging stations, onsite gym, and wellness benefits. (For US only, benefits in other countries may vary.) 

 

#LI-Hybrid #LI-KK1

Salary : $98,000 - $115,000

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