What are the responsibilities and job description for the Senior Scientist position at NextGen Tides?
Company Description
NextGen Tides is an innovative biotech startup focused on oligonucleotide and peptide synthesis, conjugation technologies, and next-gen modality services (ASO, siRNA, PMO, AOC, etc.). We are building a top-tier, flexible CRO/CDMO platform that enables discovery-to-preclinical workflows for pharma, biotech, and academic partners worldwide.
POSITION SUMMARY:
The Principal/Senior Scientist, Oligonucleotides will establish Analytical capability in
separation science, and characterization within NextGen Tides’s oligonucleotides
platform supporting synthesis group and customer’s requests. In this visible role, the
candidate will be responsible for the Analytical and Purification method development of
novel modified oligonucleotides multiple modalities including ASO, siRNA, PMO, and
ligand-oligo-conjugation leveraging high-throughput automation and screening
workflows. This individual will have direct experience with analysis, purification, and
analytics of oligonucleotides and nucleoside analogs, as well as demonstrated ability to
work as part of an integrated team on multiple projects. He/She will have in depth
experience in the field of oligonucleotide/peptide therapeutics with knowledge in
chemical structure search tools, purification instrumentation, and analysis methods
related to chemically modified oligonucleotides. He/She will interact with all levels of the
organization and take on substantial ownership within NextGen Tides’s scientific
function. The successful candidate will focus on Method Development and Analysis of
oligonucleotides, and analytical characterization of multiple modalities. Leading through
contributions at the bench, the selected candidate will serve as Lead Oligonucleotide
Scientist for Analytical Team.
Key Responsibilities
- Serve as the Lead Oligonucleotide Scientist in cross-functional teams with
accountability for oligos purification and analytical analysis.
- Take a leadership role in maintaining all aspects of analytical/ purification
instrumentation and operations in the oligonucleotide laboratory.
- Develop and maintain standard operating procedures (SOPs) for processing,
purification, and analytical characterization to ensure high-quality and
reproducible results.
- Establish and maintain high-throughput automation workflows to support small
and mid-scale purification and analysis of ASOs, siRNA, PMO, and ligand-oligo-
conjugation with routine and novel next generation amidite synthesis.
- Establish and routinely perform oligos purification using ÄKTA and analytical
characterization workflows.
- Troubleshoot, operate and oversee the interpretation of data from LC-MS as well
as analytical and preparative HPLC.
- Work closely with synthesis and bioconjugation chemists to develop a seamless
workflow to support manufacturing of novel targeting ligands (e.g., peptide,
antibody, etc).
- With the growth of NextGen Tides, train and/or build a small team of research
associates to support oligos purification and analytical analysis capabilities.
- supervise and/or lead associates in a cross functional team environment.
- Demonstrate excellent written and verbal communication skills.
- Convey novel innovations at the project team level.
Qualifications & Experience
- A doctorate degree in Chemistry, Chemical Biology, Organic/Medicinal
Chemistry, or a related field.
- A minimum of 3 (Senior Scientist) or 6 (Principal Scientist) years of firsthand
industry experience in modern synthetic chemistry methods particularly in
nucleosides, nucleotides, and oligonucleotide synthesis, purification, and
analysis in pharmaceutical or biotechnology settings.
- Direct experience setting up and operating different instruments used in
oligonucleotides purification (e.g., ÄKTA Avant/Pure with Unicorn Software,
tangential flow filtration), analysis (e.g., UPLC, LC/MS, LC/HRMS), and
lyophilizes.
- A dependable contributor to cross-functional teams who embrace a collaborative
culture while demonstrating the autonomy and initiative required to deliver on
assigned scientific and operational responsibilities.
- Demonstrated ability to troubleshoot instrumentation and complex scientific
problems and adapt to shifting priorities in a fast-paced, quality-driven
environment.
- Prior experience in discovery of therapeutic oligonucleotides is highly desirable.
Compensation&Benefits
- Competitive base salary commission
- Equity incentives for high performers
- 401(k) with employer contribution
- Health benefits and family medical coverage
- Vacation & PTO policy
- Opportunities to grow into principle/VP