Demo

Postdoctoral Fellow - DNA repair, Epigenome

National Institutes of Health and Careers
Bethesda, MD Full Time
POSTED ON 4/14/2026
AVAILABLE BEFORE 5/14/2026

About the position

The Neuro-Oncology Branch (NOB) at the National Cancer Institute’s Center for Cancer Research (CCR) is a specialized program dedicated to advancing the study and treatment of brain and central nervous system (CNS) tumors. We are seeking an exceptional candidate to join our Molecular and Cell Biology (MCB) Program. This position focuses on investigating DNA repair pathways in brain tumors, with an emphasis on identifying and characterizing critical epigenetic targets through genetic and biochemical approaches. Mechanistic insights will be validated using in vitro and in vivo models, as well as patient-derived specimens.

In addition, experimental therapeutics will be developed based on preliminary findings. These discoveries are expected to provide a strong foundation for future clinical translation and therapeutic applications.

Position Highlights:

  • Outstanding Training: Combine basic mechanistic research with disease-relevant preclinical research.
  • Advanced Models: Utilize both mouse models, patient-derived xenografts (PDXs), and human specimens to develop next-generation therapeutics.
  • Collaborative Medicinal Research: Work in a dynamic, collaborative, and interdisciplinary research team.
  • State-of-the-Art Resources: Access state-of-the-art research facilities and resources, including equipment, computational tools, and reagents.
  • Exciting Research Environment: Benefit from well-equipped in-house core facilities and intense collaborations among laboratories.
  • Expert Mentorship: Receive guidance from renowned scientists and clinicians, gaining invaluable knowledge in the field.

Qualifications and Job Details

  • Degree Required Ph.D. or equivalent
  • Job Location Bethesda
  • Appointment Type Training Position (Starting stipend: $67,200)
  • Work Schedule: Full-time (In-Person)
  • Citizenship: US citizenship or permanent residency not required


What you'll need to apply

  • CV/Resume
  • 3 References
  • Summary of Research Experience

Contact name

Chunzhang Yang

Contact email

yangc2@nih.gov

Qualifications

The ideal candidate should be able to:

  • Show interest and motivation to investigate fundamental questions in cancer biology and functional genomics.
  • Leverage a background in biochemistry and molecular biology, emphasizing signal transduction, cancer cell biology, cell cycle, or DNA repair.
  • Collaborate with the Principal Investigator (PI) for hypothesis development, experimental design, and execution.
  • Participate in data processing, analysis, discussion, reporting, presenting findings at conferences, and manuscript drafting.
  • Work effectively within an interdisciplinary team.
  • Stay informed of developments in the field to maintain and enhance professional expertise.
  • Perform lab maintenance, including equipment upkeep and supply ordering.
  • Teach techniques to train and mentor junior research staff.
  • Demonstrate excellent communication skills and fluency in both spoken and written English.

Disclaimer/Fine Print

U.S. citizens and permanent residents are eligible to apply.

Salary : $67,200

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