What are the responsibilities and job description for the Principal Investigator position at Metric?
Opportunity: Principal Investigator (General Medicine)
Metric Bio is partnering with a high-performing and rapidly expanding clinical site network based in Massachusetts, in the search for an accomplished Principal Investigator specialising in General Medicine. This is a unique opportunity to lead meaningful clinical research, drive innovation, and directly impact patient outcomes within a cutting-edge US-based organisation.
The Role:
As the Principal Investigator, you will provide expert medical leadership across multiple clinical trials, ensuring scientific integrity, regulatory compliance, and the highest standards of patient safety. You’ll be a key contributor in shaping research strategy, guiding clinical teams, and building strong collaborations with sponsors and stakeholders.
Key Responsibilities
- Serve as the lead Principal Investigator across general medicine clinical trials
- Oversee all aspects of study conduct, ensuring alignment with protocol, GCP, and FDA standards
- Conduct medical evaluations, determine eligibility, and monitor patient safety
- Provide expert input into feasibility assessments and study design
- Safeguard data quality and ethical integrity across trials
- Develop and maintain strong sponsor and regulator relationships
- Mentor and support Sub-Investigators and research teams
- Champion clinical excellence and continuous process improvement
Required Qualifications & Experience
- MD/DO with active and unrestricted US medical license.
- Minimum 5 years’ post-licensure experience in general or internal medicine
- Direct involvement in 10 or more clinical trials (Phase II–IV preferred) as Principal Investigator or Sub-Investigator.
- Deep understanding of GCP, FDA regulations, ICH guidelines, and clinical governance
- Proven track record in clinical leadership and decision-making
- Excellent communication, patient-centric approach, and collaborative mindset
What’s on Offer
- Competitive compensation package comprehensive benefits
- Opportunity to lead high-impact trials across varied therapeutic areas
- Innovative, collaborative research environment
- Professional development & leadership support
- Make a significant contribution to improving future patient care
Interested in Applying?
If you are an experienced physician with a passion for research leadership and meet the clinical trial experience requirement, we would love to hear from you.
Contact Metric Bio: oli.oldham@metric-search.com
Salary : $160 - $350