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QA/Computer System Validation SME

Jobs via Dice
South San Francisco, CA Full Time
POSTED ON 6/5/2026
AVAILABLE BEFORE 7/4/2026
Dice is the leading career destination for tech experts at every stage of their careers. Our client, Algo Soft Solutions LLC, is seeking the following. Apply via Dice today!

QA/CSV SME

MUST haves - Clinical Systems Validation (Veeva eTMF, Medidata Rave, Clinical Data Repositories)

  • Provide QA oversight for Computer System Validation (CSV) activities across GxP-regulated clinical and biopharmaceutical systems, ensuring compliance with FDA 21 CFR Part 11, GAMP 5, and applicable regulatory requirements.
  • Review and approve validation deliverables including Validation Plans, User Requirements Specifications (URS), Functional Specifications (FS), Risk Assessments, IQ/OQ/PQ protocols, Test Scripts, Traceability Matrices, and Validation Summary Reports.
  • Partner with Business, IT, Clinical Operations, and Quality stakeholders to perform risk-based assessments, identify compliance gaps, and implement effective mitigation strategies.
  • Support end-to-end validation lifecycle activities for clinical platforms, including system implementations, upgrades, integrations, cloud migrations, and change controls.
  • Lead and support vendor qualification assessments, supplier audits, and third-party compliance evaluations to ensure validated system integrity and regulatory compliance.
  • Ensure inspection readiness by maintaining validation documentation, supporting regulatory audits, and providing responses to FDA, EMA, MHRA, and internal quality inspections.
  • Provide QA guidance and oversight for deviations, incidents, CAPAs, change controls, periodic reviews, and validation exceptions throughout the system lifecycle.
  • Develop, review, and maintain CSV-related SOPs, policies, work instructions, templates, and validation standards to support a compliant quality framework.
  • Collaborate with cross-functional teams to establish validation strategies, testing approaches, and data integrity controls based on risk and business impact.
  • Drive continuous process improvements by implementing industry best practices, CSA (Computer Software Assurance) principles, and risk-based validation methodologies.
  • Manage multiple CSV projects simultaneously, ensuring deliverables are completed on schedule while maintaining compliance and quality standards.
  • Support governance of clinical applications such as CTMS, eTMF, EDC, Safety Systems, ePRO, LMS, and other GxP-regulated platforms.
  • Conduct Data Integrity assessments and ensure compliance with ALCOA principles, electronic records, electronic signatures, and audit trail requirements.
  • Coordinate internal and external resources, monitor project progress, and provide status updates to QA leadership and project stakeholders.
  • Mentor project teams on validation compliance expectations and promote a culture of quality, regulatory adherence, and continuous improvement.

Salary.com Estimation for QA/Computer System Validation SME in South San Francisco, CA
$120,189 to $130,182
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