Demo

Senior Program Manager

Guardant Health
Palo Alto, CA Full Time
POSTED ON 6/3/2026
AVAILABLE BEFORE 7/2/2026
Company Description

Guardant Health is a leading precision oncology company focused on guarding wellness and giving every person more time free from cancer. Founded in 2012, Guardant® is transforming patient care and accelerating new cancer therapies by providing critical insights into what drives disease through its advanced blood and tissue tests, real-world data and AI analytics. Guardant tests help improve outcomes across all stages of care, including screening to find cancer early, monitoring for recurrence in early-stage cancer, and treatment selection for patients with advanced cancer. For more information, visit guardanthealth.com and follow the company on LinkedIn, X (Twitter) and Facebook.

Company Description 



Guardant Health is a leading precision oncology company focused on helping conquer cancer globally through use of its proprietary tests, vast data sets and advanced analytics. The Guardant Health oncology platform leverages capabilities to drive commercial adoption, improve patient clinical outcomes and lower healthcare costs across all stages of the cancer care continuum. Guardant Health has commercially launched Guardant360®, Guardant360 CDx, Guardant360 TissueNext™, Guardant360 Response™, and GuardantOMNI® tests for advanced stage cancer patients, and Guardant Reveal™ for early-stage cancer patients. The Guardant Health screening portfolio, including the Shield™ test, aims to address the needs of individuals eligible for cancer screening. 

Job Description:

The Senior Program Manager, New Product Development, will play a critical leadership role in bringing cutting-edge cancer diagnostics to market. This individual will lead cross-functional teams to develop and launch next-generation sequencing (NGS)–based products across Research Use Only (RUO), Laboratory Developed Tests (LDT), and In Vitro Diagnostics (IVD) applications—directly impacting patients with unmet clinical needs. 

You will lead a cross-functional core team in the development of an NGS assay, ensuring delivery of the product through launch while ensuring compliance with Guardant Health’s quality system deliverables and regulatory requirements.   Experience with IVD or Medical Device product development will be critical to the success of this role.  Successful end-to-end product development with complex systems is a must. 

You will work closely with key stakeholders across the organization, including marketing, regulatory, quality, medical affairs, reagent development, and bioinformatics teams, among others.  

Essential Duties and Responsibilities:

Program Leadership & Execution

  • Drive end-to-end program execution for NGS assay development from concept through commercialization  
  • Align cross-functional stakeholders (R&D, Operations, Quality, Regulatory, Marketing, Medical Affairs) on priorities, timelines, and deliverables  
  • Manage program plans, timelines, resources, and dependencies across multiple sub-projects  

Stakeholder & Partner Management

  • Partner with internal leadership and executive stakeholders to provide program updates and drive decision-making  
  • Lead collaboration with external partners to ensure delivery against contractual milestones  

Risk & Quality Management

  • Identify, assess, and mitigate program risks; drive issue resolution and root cause analysis  
  • Ensure timely completion of design history file (DHF) documentation and compliance with quality and regulatory requirements  
  • Prepare teams for phase gate reviews and key go/no-go decisions  

Communication & Reporting

  • Provide clear, concise program updates to core teams and executive leadership  
  • Establish effective communication frameworks across cross-functional teams  
  • Navigate ambiguity and evolving priorities in a fast-paced environment, demonstrating flexibility and sound judgment to adapt plans and drive programs forward

Basic Qualifications 

  • Bachelor’s degree in a technical or business-related field  
  • 5–8 years of program or project management experience (or 3–5 years with a master’s degree)  
  • Experience in FDA-regulated environments  
  • Demonstrated success leading cross-functional teams in product development  
  • Experience managing complex systems with multiple interdependent workstreams  

Preferred Qualifications 

  • Experience in IVD, medical devices, or diagnostics product development  
  • Experience with NGS assay development  
  • PMP or equivalent certification  
  • Familiarity with both Agile and Waterfall methodologies 

Hybrid Work Model: This section is applicable to onsite employees who are eligible for hybrid work location as specified by management and related policies. Guardant has defined days for in-person/onsite collaboration and work-from-home days for individual-focused time. All U.S. employees who live within 50 miles of a Guardant facility will be required to be onsite on Mondays, Tuesdays, and Thursdays. We have found aligning our scheduled in-office days allows our teams to do the best work and creates the focused thinking time our innovative work requires. At Guardant, our work model has created flexibility for better work-life balance while keeping teams connected to advance our science for our patients.

The annualized base salary ranges for the primary location and any additional locations are listed below. This range does not include benefits or, if applicable, bonus, commission, or equity. Each candidate’s compensation offer will be based on multiple factors including, but not limited to, geography, experience, education, job-related skills, job duties, and business need. Primary Location: Palo Alto, CA Primary Location Base Pay Range: $177,400 - $243,950 Other US Location(s) Base Pay Range: $150,790 - $207,358 If the role is performed in Colorado, the pay range for this job is: $159,660 - $219,555

Employee may be required to lift routine office supplies and use office equipment. Majority of the work is performed in a desk/office environment; however, there may be exposure to high noise levels, fumes, and biohazard material in the laboratory environment. Ability to sit for extended periods of time.

Guardant Health is committed to providing reasonable accommodations in our hiring processes for candidates with disabilities, long-term conditions, mental health conditions, or sincerely held religious beliefs. If you need support, please reach out to Peopleteam@guardanthealth.com

A background screening including criminal history is required for this role. GH will consider qualified applicants with criminal arrest or conviction histories in a manner consistent with applicable law including but not limited to the LA County Fair Chance Policies and the Fair Chance Act (Gov. Code Section 12952).

Guardant Health is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, or protected veteran status and will not be discriminated against on the basis of disability.

All your information will be kept confidential according to EEO guidelines.

To learn more about the information collected when you apply for a position at Guardant Health, Inc. and how it is used, please review our Privacy Notice for Job Applicants.

Please visit our career page at: http://www.guardanthealth.com/jobs/

Salary : $150,790 - $207,358

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