What are the responsibilities and job description for the Cell Line Development & Upstream Processing Scientist position at Demeetra?
Location: Lexington, KY
Company: Demeetra
Demeetra is seeking a highly motivated Cell Line Development & Upstream Processing Scientist to join our fast-paced team advancing next-generation gene editing technologies in bioproduction. This role is designed for someone who is eager, hands-on, detail-driven, and experienced enough to contribute with minimal onboard training. The successful candidate must be driven by a culture of excellence and ready for intense, high-expectation, hands-on CLD workflows, bringing industry experience that enables them to contribute at a high level from day one, ideally in a CRO or CDMO setting.
About the Role
You will be a key contributor in developing engineered CHO cell lines and optimizing upstream processes that support Demeetra’s cutting-edge gene editing platforms. This position is not for recent graduates—ideal candidates bring 2–5 years of direct industry experience, preferably from a CDMO or CLD environment, and are eager to take ownership of experimental design, workflow execution, and timeline-driven deliverables.
Responsibilities
- Execute CHO cell culture processes across shake flasks, spin tubes, and deep-well plate fed-batch formats
- Perform transfection, selection, clone screening, and single-cell cloning workflows
- Support upstream development with high attention to process consistency and data integrity
- Run titer and basic downstream quality assays to assess productivity and cell line performance
- Collaborate cross-functionally to implement advanced gene editing technologies in CLD
- Contribute to workflow design, documentation, and continuous process improvement
- Maintain a culture of excellence, accountability, and meeting or exceeding timelines
Required Qualifications
- PhD in biology, biochemistry, biotechnology, or related field required
- 2–5 years industry experience in cell line development or upstream processing (CDMO or CLD company strongly preferred)
- Demonstrated proficiency in:
- Molecular Biology and vector design
- CHO cell culture
- Transfection & selection workflows
- Shake flask, spin tube, and deep-well plate fed-batch processes
- Single-cell cloning
- Titer determination and standard downstream quality assessments
- Ability to thrive in a high-expectation, fast-moving environment
- Strong communication, organization, and documentation skills
Salary Range: $100K to $130K
Why Join Demeetra?
This is an opportunity to join a growing company at the forefront of gene editing applied to cell line development and bioprocessing. You will have significant hands-on impact, work with advanced technologies, and be part of an intensely collaborative and rewarding environment.
Salary : $100,000 - $130,000