Senior Manager, Human Resources

About Us

Crescent Biopharma’s vision is to build a world leading oncology company bringing the next wave of therapies for cancer patients. The Company’s clinical-stage pipeline includes its lead program, a PD-1 x VEGF bispecific antibody, as well as novel antibody-drug conjugates. By leveraging multiple modalities and established targets, Crescent aims to rapidly advance potentially transformative therapies either as single agents or as part of combination regimens to treat a range of solid tumors. For more information, visit www.crescentbiopharma.com and follow the Company on LinkedIn and X.

Position Overview

The Senior Manager, Human Resources is responsible for the day-to-day execution of core HR operations, ensuring processes are efficient, compliant, and consistently delivered. This highly hands-on role serves as a primary point of contact for employees and managers, supporting the full employee lifecycle while delivering a positive, well-run employee experience.

The ideal candidate is detail-oriented, organized, and comfortable managing multiple HR functions simultaneously.

• Administer benefits and compensation programs accurately and on schedule.
• Own HRIS, employee records, and documentation, ensuring accuracy, confidentiality, and compliance.
• Manage leave of absence requests and administration.
• Partner with Payroll and Finance to ensure accurate and timely payroll processing.
• Support recruiting efforts, including offer letters, onboarding coordination, and pre-employment requirements.
• Oversee and enhance onboarding and offboarding processes, including new hire paperwork, orientation, and exit interviews.
• Serve as primary contact for employee benefits questions, enrollments, and changes; liaise with benefit providers.
• Manage purchase orders (POs) related to HR operations.
• Ensure compliance with federal, state, and local employment laws.
• Maintain and update employee handbook, policies, and procedures.
• Act as first point of contact for HR-related inquiries, providing guidance and timely resolution.
• Support employee engagement initiatives by promoting consistent HR practices, and clear communication that reinforces company values.
• Identify opportunities to improve HR processes and documentation for efficiency and employee experience.
• Prepare and maintain routine HR reports and metrics to support decision-making and compliance.

• Bachelor’s degree in Human Resources, Business Administration, or related field.
• A minimum of 5 years of HR experience, with a strong background in HR operations, ideally in a growing organization.
• Experience in biotech, pharma, or life sciences preferred.
• Solid knowledge of HRIS systems, payroll, and benefits administration.
• Strong understanding of employment law and compliance requirements.
• Excellent organizational skills and ability to manage multiple competing priorities.
• Strong analytical, strategic thinking, and problem-solving skills.
• Proven ability to communicate effectively across all levels of the organization.
• Commitment to fostering a diverse and inclusive workplace. 

• Opportunity to join a mission-driven team where you'll contribute to impactful work, take on varied responsibilities, and grow quickly in a dynamic environment.
• Competitive compensation, including base salary, performance bonus, and equity.
• 100% employer-paid benefits package.
• Flexible PTO.
• Two, one-week company-wide shutdowns each year.
• A commitment to your professional development, with access to resources, mentorship, and growth opportunities. 

The anticipated base pay range for this position is :

$172,000 to $190,000 USD.

Additional Description for Pay Transparency:

Subject to the terms of their respective plans, employees and/or eligible dependents are eligible to participate in the following Company sponsored employee benefit programs: medical, dental, vision, life insurance, short- and long-term disability. Subject to the terms of their respective plans, employees are eligible to participate in the Company’s savings plan (401(k)). This position is eligible to participate in the Company’s long-term incentive program. Subject to the terms of their respective policies and date of hire, Employees are eligible for the following time off benefits: Vacation – Unlimited PTO; Sick time – 10 days per calendar year; Holiday pay, including two Company shut downs; Parental Leave – 16 weeks within one year of the birth/adoption/foster care of a child; FMLA; Military Leave. Additional information can be found through the link below. https://www.crescentbiopharma.com/careers/#benefits

E-Verify:

Crescent Biopharma, Inc. uses E-Verify to confirm the identity and employment eligibility of all new hires.

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Crescent Biopharma is an Equal Opportunity Employer. We are committed to fostering a diverse, inclusive, and equitable workplace where all individuals are valued and respected. Employment decisions are based on qualifications, merit, and business needs, without regard to race, color, religion, gender, sexual orientation, national origin, disability, veteran status, or any other protected status.

Salary : $172,000 - $190,000